In pharmacology, an indirect agonist or indirect-acting agonist is a substance that enhances the release or action of an endogenous neurotransmitter but has no specific agonist activity at the neurotransmitter receptor itself. Indirect agonists work through varying mechanisms to achieve their effects, including transporter blockade, induction of transmitter release, and inhibition of transmitter breakdown.
In pharmacology, an indirectagonist or indirect-acting agonist is a substance that enhances the release or action of an endogenous neurotransmitter but...
UV-photons Indirectagonist or indirect-acting agonist, a substance that enhances the release or action of an endogenous neurotransmitter Indirect speech...
A dopamine agonist (DA) is a compound that activates dopamine receptors. There are two families of dopamine receptors, D1-like and D2-like. They are all...
directly or indirectly. Direct-binding agonists can be further characterized as full agonists, partial agonists, inverse agonists. Direct agonists act similar...
oxidase inhibitors (e.g., phenelzine, moclobemide) are indirect non-selective serotonin receptor agonists. They are used variously as antidepressants, anxiolytics...
the activity of PKA. Agonists of each class of receptor elicit these downstream responses. Indirectly acting adrenergic agonists affect the uptake and...
modulators of GABA-A receptors but also direct agonists of these receptors. Alcohol is an indirect GABA agonist. GABA is the major inhibitory neurotransmitter...
source?] Because of this, mirtazapine has been said to be a functional "indirectagonist" of the 5-HT1A receptor. Increased activation of the central 5-HT1A...
reuptake inhibitor and releasing agent. Hence, it functions as an indirectagonist of dopamine receptors. Pemoline has little effect on norepinephrine...
C23H38O4; 20:4, ω-6), respectively, therefore, it can also act as an indirectagonist at the cannabinoid receptors, by enhancing the activity of the endocannabinoid...
and acts similarly to it as a prodrug of GABA, and therefore as an indirectagonist of the GABA receptors. Progabide Fengabine Triggle DJ (1996). Dictionary...
little affinity for CB1 and CB2 receptors but acts as an indirect antagonist of cannabinoid agonists. It was found to be an antagonist at the putative new...
drug and receptor), such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting (interaction not between drug and...
cognition-enhancing effects in humans have evidence in vitro as direct agonists or indirectagonists of dopamine receptor D1 or adrenoceptor A2. Relatively high...
efficacious dopaminergic reuptake inhibitor (also called a dopamine indirectagonist). These effects were mainly observed in the nucleus accumbens, a region...
dopamine receptor antagonists while psychostimulants are typically indirectagonists of dopamine receptors. The existence of multiple types of receptors...
direct alpha-adrenergic agonist and β1 adrenergic agonist effects. However at doses common in clinical practice, the indirect α1 adrenergic effects predominate...
robustly as D2 receptor agonists, and as such, they are not usually used as prolactin inhibitors. Whereas D2 receptor agonists suppress prolactin secretion...
TAAR1 – α2A TAAR1 – TAAR2 Trace amines are endogenous amines which act as agonists at TAAR1 and are present in extracellular concentrations of 0.1–10 nMTooltip...
impairments were reversed when treated with physostigmine, a cholinergic agonist. However, reversing memory impairments in AD patients may not be this easy...
application of selective D1 dopamine receptor agonists (such as the partial agonist SKF38393 or the full agonist SKF81297) and antagonist (such as SCH23390)...
ions through the cell membrane. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to...
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