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Amifostine information


Amifostine
Clinical data
AHFS/Drugs.comMonograph
Routes of
administration
Intravenous
ATC code
  • V03AF05 (WHO)
Legal status
Legal status
  • US: ℞-only
Pharmacokinetic data
Bioavailabilitycomplete
Elimination half-life8 minutes
Identifiers
IUPAC name
  • 2-(3-aminopropylamino)ethylsulfanylphosphonic acid
CAS Number
  • 112901-68-5 checkY
  • anhydrous: 20537-88-6 checkY
PubChem CID
  • 2141
DrugBank
  • DB01143 checkY
ChemSpider
  • 2056 checkY
UNII
  • M487QF2F4V
  • anhydrous: ILA426L95O checkY
KEGG
  • C06819 checkY
ChEBI
  • CHEBI:2636 checkY
ChEMBL
  • ChEMBL1006 checkY
CompTox Dashboard (EPA)
  • DTXSID8022585 Edit this at Wikidata
ECHA InfoCard100.161.827 Edit this at Wikidata
Chemical and physical data
FormulaC5H15N2O3PS
Molar mass214.22 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=P(O)(O)SCCNCCCN
InChI
  • InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10) checkY
  • Key:JKOQGQFVAUAYPM-UHFFFAOYSA-N checkY
  (verify)

Amifostine (ethiofos) is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. It is marketed by Clinigen Group under the trade name Ethyol.

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Amifostine

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Amifostine (ethiofos) is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. It is marketed...

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Organothiophosphate

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Selected organothiophosphates Echothiophate used for treatment of glaucoma Amifostine, which is used in cancer chemotherapy Chlorpyrifos, a common insecticide...

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Schedule H

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ALPHACHYMOTRYPSIN 15. ALPRAZOLAM 16. ALPROSTADIL 17. AMANTADINE HYDROCHLORIDE 18. AMIFOSTINE 19. AMIKACIN SULPHATE 20. AMILORIDE HYDROCHLORIDE 21. AMINEPTINE 22. AMINOGLUTETHIMIDE...

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Xerostomia

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review showed, that there is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth or reduce the risk of moderate to severe...

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Ototoxicity

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decreased uptake of the drug by cells of the cochlea. Administration of amifostine has been used in attempts to prevent cisplatin-induced ototoxicity, but...

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Cisplatin

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explored clinically and pre-clinically, including hydration regimens, amifostine, transporter inhibitors, antioxidants, anti-inflammatories, and epoxyeicosatrienoic...

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Chemoprotective agent

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end result, improves the patients' quality of life. Examples include: Amifostine, approved by the FDA in 1995, which helps prevent kidney damage in patients...

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Head and neck cancer

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chemotherapy, amifostine is often administered intravenously by a chemotherapy clinic prior to IMRT radiotherapy sessions. Amifostine protects the gums...

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ATC code V03

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Dexrazoxane V03AF03 Calcium folinate V03AF04 Calcium levofolinate V03AF05 Amifostine V03AF06 Sodium folinate V03AF07 Rasburicase V03AF08 Palifermin V03AF09...

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Pyridoxamine

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ionizing radiation-induced gastrointestinal epithelial apoptosis than amifostine (the only radioprotector currently Food and Drug Administration (FDA)-approved)...

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Dexrazoxane

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S, Jokanovic M, Jovic V (December 2007). "Effects of dexrazoxane and amifostine on evolution of Doxorubicin cardiomyopathy in vivo". Experimental Biology...

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Thiophosphate

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oil additive. Phosphorothioates are the basis for antisense therapies. Amifostine, which is used in cancer chemotherapy. Chlorpyrifos, a popular insecticide...

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Cystamine

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PMID 7648421. Kuna, Pavel (2004). "Acute toxicity and radioprotective effects of amifostine (WR-2721) or cystamine in single whole body fission neutrons irradiated...

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Armed Forces Radiobiology Research Institute

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and training. AFRRI has contributed significantly to the development of Amifostine, Neupogen, Neulasta, Nplate, and Leukine, a series of drugs treating or...

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Southern Research

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carmustine, lomustine, dacarbazine developed by Y Fulmer Shealy, fludarabine, amifostine, clofarabine and the latest pralatrexate (approved in 2009). Notable cancer...

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ALPI

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the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity". Seminars in Oncology. 29 (6 Suppl 19): 14–21. doi:10.1053/sonc...

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Index of oncology articles

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vaccine – Amanita phalloides – Ambien – amelanotic melanoma – Ames, Bruce – amifostine – amikacin – aminocamptothecin – aminoglutethimide – aminoglycoside antibiotic...

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