The trigeminal nerve and its three major divisions (shown in yellow): the ophthalmic nerve (V1), the maxillary nerve (V2), and the mandibular nerve (V3)
Specialty
Neurology
Symptoms
Typical: episodes of severe, sudden, shock-like pain in one side of the face that lasts for seconds to minutes[1] Atypical: constant burning pain[1]
Complications
Depression[5]
Usual onset
> 50 years old[1]
Types
Typical and atypical trigeminal neuralgia[1]
Causes
Believed to be due to problems with myelin of trigeminal nerve[1][6]
Diagnostic method
Based on symptoms[1]
Differential diagnosis
Postherpetic neuralgia[1]
Treatment
Medication, surgery[1]
Medication
Carbamazepine, oxcarbazepine[6]
Prognosis
80% improve with initial treatment[6]
Frequency
1 in 8,000 people per year[1]
Trigeminal neuralgia (TN or TGN), also called Fothergill disease, tic douloureux, trifacial neuralgia, or suicide disease, is a long-term pain disorder that affects the trigeminal nerve,[7][1] the nerve responsible for sensation in the face and motor functions such as biting and chewing. It is a form of neuropathic pain.[8] There are two main types: typical and atypical trigeminal neuralgia.[1] The typical form results in episodes of severe, sudden, shock-like pain in one side of the face that lasts for seconds to a few minutes.[1] Groups of these episodes can occur over a few hours.[1] The atypical form results in a constant burning pain that is less severe.[1] Episodes may be triggered by any touch to the face.[1] Both forms may occur in the same person.[1] It is regarded as one of the most painful disorders known to medicine, and often results in depression and suicide.[5]
The exact cause is unknown, but believed to involve loss of the myelin of the trigeminal nerve.[1][6] This might occur due to compression from a blood vessel as the nerve exits the brain stem, multiple sclerosis, stroke, or trauma.[1] Less common causes include a tumor or arteriovenous malformation.[1] It is a type of nerve pain.[1] Diagnosis is typically based on the symptoms, after ruling out other possible causes such as postherpetic neuralgia.[8][1]
Treatment includes medication or surgery.[1] The anticonvulsant carbamazepine or oxcarbazepine is usually the initial treatment, and is effective in about 90% of people.[8] Side effects are frequently experienced that necessitate drug withdrawal in as many as 23% of patients.[8] Other options include lamotrigine, baclofen, gabapentin, amitriptyline and pimozide.[6][1] Opioids are not usually effective in the typical form.[1] In those who do not improve or become resistant to other measures, a number of types of surgery may be tried.[6]
It is estimated that trigeminal neuralgia affects around 0.03% to 0.3% of people around the world with a female over-representation around a 3:1 ratio between women and men.[9] It usually begins in people over 50 years old, but can occur at any age.[1] The condition was first described in detail in 1773 by John Fothergill.[10]
^ abcdefghijklmnopqrstuvwxyz"Trigeminal Neuralgia Fact Sheet". NINDS. National Institutes of Health. 17 March 2020. Retrieved 5 April 2021.
^Hackley CE (1869). A text-book of practical medicine. D. Appleton & Co. p. 292. Retrieved 2011-08-01. prosopalgia.
^Bagheri SC, Farhidvash F, Perciaccante VJ (December 2004). "Diagnosis and treatment of patients with trigeminal neuralgia". Journal of the American Dental Association. 135 (12): 1713–1717. doi:10.14219/jada.archive.2004.0124. PMID 15646605. Archived from the original on July 11, 2012. Retrieved 2011-08-01.
^Adams H, Pendleton C, Latimer K, Cohen-Gadol AA, Carson BS, Quinones-Hinojosa A (May 2011). "Harvey Cushing's case series of trigeminal neuralgia at the Johns Hopkins Hospital: a surgeon's quest to advance the treatment of the 'suicide disease'". Acta Neurochirurgica. 153 (5): 1043–1050. doi:10.1007/s00701-011-0975-8. PMID 21409517. S2CID 28245294.
^ abOkeson JP (2005). "6". In Lindsay Harmon (ed.). Bell's orofacial pains: the clinical management of orofacial pain. Quintessence Publishing Co, Inc. p. 114. ISBN 0-86715-439-X. Archived from the original on 2014-01-12.
^ abcdefObermann M (March 2010). "Treatment options in trigeminal neuralgia". Therapeutic Advances in Neurological Disorders. 3 (2): 107–115. doi:10.1177/1756285609359317. PMC 3002644. PMID 21179603.
^"Trigeminal Neuralgia". National Organization for Rare Disorders, Inc. 26 February 2014.
^ abcdCruccu G, Di Stefano G, Truini A (August 2020). Ropper AH (ed.). "Trigeminal Neuralgia". The New England Journal of Medicine. 383 (8): 754–762. doi:10.1056/NEJMra1914484. PMID 32813951. S2CID 221201036.
^Araya EI, Claudino RF, Piovesan EJ, Chichorro JG (2020-01-23). "Trigeminal Neuralgia: Basic and Clinical Aspects". Current Neuropharmacology. 18 (2): 109–119. doi:10.2174/1570159X17666191010094350. PMC 7324879. PMID 31608834.
^Prasad S, Galetta S (March 2009). "Trigeminal neuralgia: historical notes and current concepts". The Neurologist. 15 (2): 87–94. doi:10.1097/nrl.0b013e3181775ac3. PMID 19276786. S2CID 23500191.
and 26 Related for: Trigeminal neuralgia information
Trigeminalneuralgia (TN or TGN), also called Fothergill disease, tic douloureux, trifacial neuralgia, or suicide disease, is a long-term pain disorder...
Atypical trigeminalneuralgia (ATN), or type 2 trigeminalneuralgia, is a form of trigeminalneuralgia, a disorder of the fifth cranial nerve. This form...
glossopharyngeal neuralgia. Under the general heading of neuralgia are trigeminalneuralgia (TN), atypical trigeminalneuralgia (ATN), occipital neuralgia, glossopharyngeal...
Postherpetic neuralgia (PHN) is neuropathic pain that occurs due to damage to a peripheral nerve caused by the reactivation of the varicella zoster virus...
glycerol into the trigeminal ganglion has been used in the treatment of trigeminalneuralgia.[citation needed] In rodents, the trigeminal ganglion is important...
"The Trigeminal Nerve (CN V)". TeachMeAnatomy. Retrieved 5 April 2021. Kontzialis M, Kocak M (2017). "Imaging evaluation of trigeminalneuralgia". Journal...
cerebellum, the midbrain, and other nearby structures. It is the cause of trigeminalneuralgia in some patients. The superior cerebellar artery arises near the...
and trigeminalneuralgia. Carbamazepine is the only medication that is approved by the Food and Drug Administration for the treatment of trigeminal neuralgia...
intraoral approach. The infraorbital nerve can be implicated in trigeminalneuralgia, where patients have severe orofacial pain. A fracture of the floor...
and harder to treat.[citation needed] Trigeminalneuralgia (or "tic douloureux") is a disorder of the trigeminal nerve that causes episodes of intense...
prostaglandins). There is some suggestion that AFP is an early form of trigeminalneuralgia. Pain may be referred from other parts of the head or other parts...
tearing (SUNCT) is a headache syndrome belonging to the group of TACs. Trigeminalneuralgia is a unilateral headache syndrome, or "cluster-like" headache. Management...
is a neurosurgical procedure used to treat trigeminalneuralgia (along with other cranial nerve neuralgias), a pain syndrome characterized by severe episodes...
trigeminal artery has been identified as a rare cause of trigeminalneuralgia, with 2.2% prevalence of persistent trigeminal artery among trigeminal neuralgia...
Oslo]. Dagbladet (in Norwegian). "Facial Neuralgia Resources". TrigeminalNeuralgia Resources / Facial Neuralgia Resources. Archived from the original on...
serious adverse effects necessitating hospital admission, for instance trigeminalneuralgia can present as a severe crisis where the patient may have difficulty...
Intradural procedures, such as removal of a brain tumour or treatment of trigeminalneuralgia via a microvascular decompression, require that an incision is made...
the trigeminal nerve leads to loss of sensation in an affected area. Other conditions affecting the trigeminal nerve (V) include trigeminalneuralgia, herpes...
Pharmaceuticals for the treatment of lumbosacral radiculopathy (sciatica) and trigeminalneuralgia (TGN). Vixotrigine was originally claimed to be a selective central...
war, she is known to have also suffered from severe depression and trigeminalneuralgia. This condition affects a nerve in the face, and although usually...
evidence supporting the use of misoprostol for the treatment of trigeminalneuralgia in patients with multiple sclerosis. The most commonly reported adverse...
Honours for charitable service. Aneeta's experience of bilateral TrigeminalNeuralgia began in 2010, with severe pain and resulting sleep deprivation....
Preherpetic neuralgia is a form of nerve pain (neuralgia) specifically associated with a Shingles (herpes zoster) viral infection. This nerve pain often...
purposes, such as treating severe facial pain, such as that caused by trigeminalneuralgia. Botulinum toxin produced by C. botulinum is often believed to be...
surgery involving any part of the trigeminal system, and occurs after 1–4% of peripheral surgery for trigeminalneuralgia. No effective medical therapy has...