Online database containing information on drugs and drug targets
DrugBank
Content
Description
Drug database
Data types captured
Chemical structures, small molecule drugs, biotech drugs, drug targets, drug transporters, drug target sequences, drug target SNPs, drug metabolites, drug descriptions, disease associations, dosage data, food and drug interactions, adverse drug reactions, pharmacology, mechanisms of action, drug metabolism, chemical synthesis, patent and pricing data, chemical properties, nomenclature, synonyms, chemical taxonomy, drug NMR spectra, drug GC-MS spectra, drug LC-MS spectra
Contact
Research center
University of Alberta and The Metabolomics Innovation Centre, Alberta, Canada
Laboratory
David S. Wishart
Primary citation
DrugBank: a comprehensive resource for in silico drug discovery and exploration.[1]
Access
Website
www.drugbank.com
Download URL
www.drugbank.ca/downloads
Miscellaneous
Data release frequency
Every 2 years with monthly corrections and updates
Curation policy
Manually curated
The DrugBank database is a comprehensive, freely accessible, online database containing information on drugs and drug targets created and maintained by the University of Alberta and The Metabolomics Innovation Centre located in Alberta, Canada.[1] As both a bioinformatics and a cheminformatics resource, DrugBank combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.[1][2] DrugBank has used content from Wikipedia;[3] Wikipedia also often links to Drugbank, posing potential circular reporting issues.[3]
The DrugBank Online website is available to the public as a free-to-access resource. However, use and re-distribution of content from DrugBank Online or the underlying DrugBank Data, in whole or part, and for any purpose requires a license. Academic users can apply for a free license for certain use cases while all other users require a paid license.
The latest release of the database (version 5.0) contains 9591 drug entries including 2037 FDA-approved small molecule drugs, 241 FDA-approved biotech (protein/peptide) drugs, 96 nutraceuticals and over 6000 experimental drugs.[4] Additionally, 4270 non-redundant protein (i.e. drug target/enzyme/transporter/carrier) sequences are linked to these drug entries. Each DrugCard entry (Fig. 1) contains more than 200 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data.[4]
Four additional databases, HMDB,[5] T3DB,[6] SMPDB[7] and FooDB are also part of a general suite of metabolomic/cheminformatic databases. HMDB contains equivalent information on more than 40,000 human metabolites, T3DB contains information on 3100 common toxins and environmental pollutants, SMPDB contains pathway diagrams for nearly 700 human metabolic pathways and disease pathways, while FooDB contains equivalent information on ~28,000 food components and food additives.
^ abcWishart, DS; Knox C; Guo AC; et al. (Jan 2006). "DrugBank: a comprehensive resource for in silico drug discovery and exploration". Nucleic Acids Research. 34 (Database issue): D668-72. doi:10.1093/nar/gkj067. PMC 1347430. PMID 16381955.
^Wishart, DS; Knox C; Guo AC; et al. (Jan 2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic Acids Research. 36 (Database issue): D901-6. doi:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
^ abHarrison, Stephen (7 March 2019). "The Dizzying Problem of Citationless Wikipedia "Facts" That Take On a Life of Their Own". Slate Magazine. Retrieved 9 November 2019.
information. DrugBank has used content from Wikipedia; Wikipedia also often links to Drugbank, posing potential circular reporting issues. The DrugBank Online...
(2002-06-08). "U.S. Lets Drug Tied to Deaths Back on Market". The New York Times. ISSN 0362-4331. Retrieved 2021-07-20. DrugBank. "Amineptine". Archived...
Drugged: the science and culture behind psychotropic drugs. Oxford University Press. ISBN 978-0-19-995797-2. DrugBank, a database of 13,400 drugs and...
ISBN 978-0-7295-3929-6. "Morphine". DrugBank. 16 October 2018. Retrieved 16 October 2018. "Pharmacology Glossary". "Propranolol". DrugBank. 16 October 2018. Retrieved...
perspective". Current Opinion in Drug Discovery & Development. 11 (4): 559–68. PMID 18600572. Analoging in ChEMBL, DrugBank and the Connectivity Map – a free...
produced by alkylation of cysteine with chloroacetic acid. Carbocisteine. drugbank.ca Zheng JP, Kang J, Huang SG, Chen P, Yao WZ, Yang L, Bai CX, Wang CZ...
the original on 2022-08-17. Retrieved 2022-05-24. "The DrugBank database: Drotaverine". DrugBank Version 4.1. The Metabolomics Innovation Centre. Retrieved...
additional anti-inflammatory actions not shared with most other antihypertensive drugs. Hypertension. Severe depression, severe kidney failure (creatinine clearance...
well as Anased, Sedazine and Chanazine. Xylazine is a common veterinary drug used for sedation, anesthesia, muscle relaxation, and analgesia in animals...
(S)-N,α-dimethylbenzeneethanamine. "Methamphetamine: Identification". DrugBank. University of Alberta. 8 February 2013. Archived from the original on...
Sulfisoxazole List of cytochrome P450 modulators "Sulfamethoxazole". DrugBank. Retrieved 5 November 2015. Brunton L, Chabner BA, Knollman B (2011). Goodman...
freshwater shrimp tanks as planaria and hydra treatments, as well as seals. Drug interactions may occur if salicylanilides such as dibromsalan and niclosamide...
Plant Data Team. Retrieved 19 October 2015. "Rauwolfia serpentina root". DrugBank, Canadian Institutes of Health Research. 2 November 2018. Retrieved 25...
Cummings R, Le D, Pon A, Knox C, Wilson M. "Salycylic acid | DrugBank Online". DrugBank. 5.0. "Salicylic acid". Archived from the original on 2017-02-15...
When Upjohn received permission from the U.S. Food and Drug Administration (FDA) to test the new drug as medicine for hypertension they approached Charles...
doi:10.1016/S0021-9258(19)85621-1. PMID 7372662. "Benzylpenicillin". www.drugbank.ca. Archived from the original on 23 January 2019. Retrieved 22 January...
International. Archived from the original on 8 September 2005. "Diazepam". DrugBank. Archived from the original on 24 December 2006. Bråthen G, Ben-Menachem...
fold elevation in the area under the curve (AUC), resulting in a minor drug-drug interaction. The American Heart Association states that the combination...
wife sue drug maker". USA Today. Archived from the original on 28 June 2010. Ornstein C (5 December 2007). "Dennis Quaid files suit over drug mishap"....
fast-acting effects, such as sedation and analgesia. (a very high–risk drug) It was first discovered and patented by a German team working for Knoll...
databases, DrugBank, T3DB, SMPDB and FooDB are also part of the HMDB suite of databases. DrugBank contains equivalent information on ~1,600 drug and drug metabolites...
Feunang Y, Guo AC, Lo EJ, Marcu A, Grant JR, et al. "Quinine | DrugBank Online". DrugBank. 5.0. Foley M, Tilley L (February 1997). "Quinoline antimalarials:...
adverse drug reactions, and patients are at risk of hypertensive emergency triggered by foods with high tyramine content, and certain drugs. Some drugs inhibit...
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