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Developmental pluripotency associated 2 information


DPPA2
Identifiers
AliasesDPPA2, CT100, ECAT15-2, PESCRG1, Developmental pluripotency associated 2
External IDsOMIM: 614445; MGI: 2157523; HomoloGene: 79572; GeneCards: DPPA2; OMA:DPPA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138815

NM_028615

RefSeq (protein)

NP_620170

NP_082891

Location (UCSC)Chr 3: 109.29 – 109.32 MbChr 16: 48.12 – 48.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Developmental pluripotency-associated protein 2 is a protein that in humans is encoded by the DPPA2 gene.[5][6][7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163530 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072419 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Du J, Lin G, Nie ZY, Lu GX (December 2004). "[Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell.]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 21 (6): 542–7. PMID 15583978.
  6. ^ "Entrez Gene: DPPA2 developmental pluripotency associated 2".
  7. ^ Klein, Rachel Herndon; Tung, Po-Yuan; Somanath, Priyanka; Fehling, Hans Joerg; Knoepfler, Paul S. (August 2018). "Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer". Stem Cell Research. 31: 83–94. doi:10.1016/j.scr.2018.07.009. ISSN 1876-7753. PMC 6133722. PMID 30031967.

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Developmental pluripotency associated 2

Last Update:

Developmental pluripotency-associated protein 2 is a protein that in humans is encoded by the DPPA2 gene. GRCh38: Ensembl release 89: ENSG00000163530...

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Induced pluripotent stem cell

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typically derived by introducing products of specific sets of pluripotency-associated genes, or "reprogramming factors", into a given cell type. The...

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Chromosome 3

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Carboxypeptidase N subunit 2 CPOX: coproporphyrinogen oxidase (coproporphyria, harderoporphyria) DPPA2: Developmental pluripotency associated 2 DTX3L: encoding protein...

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ZTTK syndrome

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of pluripotency maintenance genes. The expression of transcription factors such as the SON factor and epigenetic modifiers regulate the pluripotency of...

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Developmental biology

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Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of...

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Haruko Obokata

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Teruhiko (January 30, 2014). "Bidirectional developmental potential in reprogrammed cells with acquired pluripotency". Nature. 505 (7485): 676–680. Bibcode:2014Natur...

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SOX2

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pluripotency, an emerging and very promising field of regenerative medicine. LIF (Leukemia inhibitory factor) signaling, which maintains pluripotency...

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Bivalent chromatin

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some genes, and silencing of others during pluripotency and differentiation. H3K27me3 marks repress developmental control genes and stop the cell from differentiating...

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Gametogonium

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cells: striking the balance between pluripotency and differentiation". International Journal of Developmental Biology. 53 (2–3): 393–409. doi:10.1387/ijdb.082671pw...

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Shinya Yamanaka

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more restricted in the differentiation potential and eventually lose pluripotency. In 1962, John B. Gurdon demonstrated that the nucleus from a differentiated...

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Cellular differentiation

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prevent the use of enhancer regions of pluripotency genes, thereby inhibiting their transcription. It interacts with Mi-2/NuRD complex (nucleosome remodelling...

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Stem cell

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share many similar properties, such as pluripotency and differentiation potential, the expression of pluripotency genes, epigenetic patterns, embryoid body...

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BAP1

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genes that regulate cell fate determination, stem cell pluripotency, and other developmental processes. BAP1 is also known as: UniProt name: Ubiquitin...

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Germ layer

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Ling-Nan; Smith, Zack; Meissner, Alexander; Ramanathan, Sharad (June 2011). "Pluripotency Factors in Embryonic Stem Cells Regulate Differentiation into Germ Layers"...

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Embryonic stem cell

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cells that in subsequently differentiate into the desired cell types. Pluripotency distinguishes embryonic stem cells from adult stem cells, which are multipotent...

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Reprogramming

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used in maintaining pluripotency in stem cells. Oct4 and Sox2 work together to regulate hundreds of genes utilized in pluripotency. However, Sox2 is not...

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DPPA3

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Developmental pluripotency-associated protein 3 is a protein that in humans is encoded by the DPPA3 gene. This gene encodes a protein that in mice may...

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DMRT1

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Proliferation and Pluripotency." The DM Domain Protein DMRT1 Is a Dose-sensitive Regulator of Fetal Germ Cell Proliferation and Pluripotency. PNAS, 29 Oct...

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Homeobox protein NANOG

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maintain pluripotency by suppressing cell determination factors. hNanog is encoded in humans by the NANOG gene. Several types of cancer are associated with...

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FOXD3

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cells (EpiLC). The study proposed that Foxd3 is associated with inactivation of important naive pluripotency genes by its modification of chromatin structures...

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Yoshiki Sasai

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cells into pluripotency". Nature. 511 (7507): 112. Bibcode:2014Natur.511Q.112O. doi:10.1038/nature13598. PMID 24990753. Lawrence, Janet (July 2, 2014). "Nature...

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Human cloning

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has indicated that it was possible to replicate cells and reestablish pluripotency, or "the potential of an embryonic cell to grow into any one of the numerous...

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LIN28

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"Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28". Nature Structural & Molecular Biology. 19 (1): 84–89....

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Chromatin remodeling

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segregation as well as development and pluripotency. Aberrations in chromatin remodeling proteins are found to be associated with human diseases, including cancer...

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Muse cell

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was not 'pluripotency' but tumorigenic activity. These results collectively suggest that only preexisting cells with promising pluripotency can be programmed...

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Fibroblast

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has been studied. Whereas the fibroblasts are usually used to maintain pluripotency of the stem cells, they can also be used to facilitate development of...

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