In genetics and cell biology, repression is a mechanism often used to decrease or inhibit the expression of a gene. Removal of repression is called derepression. This mechanism may occur at different stages in the expression of a gene, with the result of increasing the overall RNA or protein products. Dysregulation of derepression mechanisms can result in altered gene expression patterns, which may lead to negative phenotypic consequences such as disease.
or inhibit the expression of a gene. Removal of repression is called derepression. This mechanism may occur at different stages in the expression of a...
D4Z4 regulatory element transcripts (DBE-T), could play a role in DUX4 derepression. One proposed mechanism is that DBE-T leads to the recruitment of the...
repressed or depressed equally. The main factor in the repression or derepression of histidine synthesis is the concentration of histidine charged tRNAs...
promotes cell arrest while phosphorylation of Rb leads to G0 exit via derepression of E2F target genes. In addition to its regulation of E2F, Rb has also...
directing growth in roots and leaf veins. The specific response to ARF derepression is thought to be mediated by specificity in the pairing of individual...
hypercellulolytic strains was to obtain a carbon catabolite derepressed strain. This derepression would allow the T. reesei strain to produce cellulases under any set...
the number of binding sites that must be added to detect target gene derepression. The discrepancies between these studies lead to different conclusions...
and patient. The influence of a good object therapist should provoke a derepression (a release from the unconscious) of the memories of abuse and neglect...
Cronenberg is more interested in neuroses and anxieties, repression and derepression, the adaptability or un-adaptability of people to strange circumstances...
addition, spermatogenesis fails due to sperm DNA damage caused by the derepression of transposable elements. MAEL has also recently been associated with...
McConnell, SK (20 November 2012). "A network of genetic repression and derepression specifies projection fates in the developing neocortex". Proceedings...
characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II". J Biol Chem. 274 (31): 21981–5...
conserved cysteine residue in the kinase domain, which correlated with derepression of EGF promoter activity and increased EGF expression, indicating that...
defects and limb polydactyly. In the developing mouse limb bud, Gli3 derepression predominantly regulates Shh target genes. Mutations in this gene have...
quiescence by switching to an irreversible pre-senescence state, caused by derepression of p16INK4a (also called Cdkn2a). On injury, these cells fail to activate...
is most commonly associated with relaxed chromatin, transcriptional derepression, and thus actively transcribed genes. Histone acetyltransferases (HATs)...
Carrión AM, Mellström B, Naranjo JR (1998). "Protein Kinase A-Dependent Derepression of the Human Prodynorphin Gene via Differential Binding to an Intragenic...
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