Formation of PSI+ prion causes S. cerevisiae cells with nonsense-mutation in ade1 gene to convert red pigment (colony below) into a colourless compound, causing colonies to become white (above)
A fungal prion is a prion that infects hosts which are fungi. Fungal prions are naturally occurring proteins that can switch between multiple, structurally distinct conformations, at least one of which is self-propagating and transmissible to other prions. This transmission of protein state represents an epigenetic phenomenon where information is encoded in the protein structure itself, instead of in nucleic acids. Several prion-forming proteins have been identified in fungi, primarily in the yeast Saccharomyces cerevisiae. These fungal prions are generally considered benign, and in some cases even confer a selectable advantage to the organism.[1]
Fungal prions have provided a model for the understanding of disease-forming mammalian prions. Study of fungal prions has led to a characterisation of the sequence features and mechanisms that enable prion domains to switch between functional and amyloid-forming states.
^Michelitsch MD, Weissman JS (2000). "A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions". Proc Natl Acad Sci U S A. 97 (22): 11910–5. Bibcode:2000PNAS...9711910M. doi:10.1073/pnas.97.22.11910. JSTOR 123764. PMC 17268. PMID 11050225.
A fungalprion is a prion that infects hosts which are fungi. Fungalprions are naturally occurring proteins that can switch between multiple, structurally...
attaching the prion domain to a reporter protein, which then aggregates like a known prion. Similarly, removing the prion domain from a fungalprion protein...
interpretation that is also strongly supported by molecular phylogenetics. This fungal group is distinct from the structurally similar myxomycetes (slime molds)...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
endophytic fungi that protect the plant from herbivores by producing toxins. The fungal endophyte Neotyphodium coenophialum in tall fescue grass has pest status...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
human or animal body by these macroparasites is usually termed infestation. Prions (although they do not secrete toxins) The signs and symptoms of an infection...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
receptor-mediated endocytosis or membrane fusion. The infection of plant and fungal cells is different from that of animal cells. Plants have a rigid cell wall...
land plant or fungus, thus excluding many unicellular groups like the fungal Microsporidia, Chytridiomycetes and yeasts, and the non-unicellular Myxozoan...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
which can cause a severe form of meningitis. Typical fungal spores are 4.7 μm long or smaller. Prions are misfolded proteins that transmit their abnormal...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
RNA may catalyze folding of the pathological protein conformation of a prion in a manner similar to that of a chaperonin. RNA can also act as a hereditary...
and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid PrionFungalprion Proteinoid microsphere Retroelements not elsewhere classified Retron...
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