SNF8 information

SNF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZME, 3CUQ
Identifiers
Aliases	SNF8, Dot3, EAP30, VPS22, ESCRT-II complex subunit, SNF8 subunit of ESCRT-II
External IDs	OMIM: 610904; MGI: 1343161; HomoloGene: 5239; GeneCards: SNF8; OMA:SNF8 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,944,842 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,938,256 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; mucosa of transverse colon; ; gastric mucosa; ; stromal cell of endometrium; ; left coronary artery; ; ganglionic eminence; ; right auricle; ; right adrenal gland; ; popliteal artery; ; tibial arteries;
	Top expressed in
	embryo; ; yolk sac; ; morula; ; dentate gyrus of hippocampal formation granule cell; ; epiblast; ; blastocyst; ; right kidney; ; superior frontal gyrus; ; facial motor nucleus; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein N-terminus binding; transcription factor binding; protein C-terminus binding; channel regulator activity; protein binding;
Cellular component	cytoplasm; recycling endosome; cytosol; endosome; membrane; late endosome membrane; transcription regulator complex; plasma membrane; nucleoplasm; perinuclear region of cytoplasm; endosome membrane; extracellular exosome; nucleus; ESCRT II complex;
Biological process	regulation of transcription, DNA-templated; positive regulation of protein catabolic process; multivesicular body sorting pathway; regulation of transcription by RNA polymerase II; multivesicular body assembly; regulation of multivesicular body size involved in endosome transport; transcription, DNA-templated; endosomal transport; regulation of protein complex stability; positive regulation of gene expression; early endosome to late endosome transport; endocytic recycling; regulation of protein catabolic process; protein transport; regulation of MAP kinase activity; positive regulation of exosomal secretion; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; macroautophagy; regulation of molecular function; transport;
	Sources:Amigo / QuickGO
Orthologs
	11267
	27681
	ENSG00000159210
	ENSMUSG00000006058
	Q96H20
	Q9CZ28
	NM_007241; NM_001317192; NM_001317193; NM_001317194
	NM_033568; NM_001356362
	NP_001304121; NP_001304122; NP_001304123; NP_009172
	NP_291046; NP_001343291
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159210 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006058 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schmidt AE; Miller T; Schmidt SL; Shiekhattar R; Shilatifard A (Aug 1999). "Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II". J Biol Chem. 274 (31): 21981–5. doi:10.1074/jbc.274.31.21981. PMID 10419521.
^ Hierro A; Sun J; Rusnak AS; Kim J; Prag G; Emr SD; Hurley JH (Sep 2004). "Structure of the ESCRT-II endosomal trafficking complex". Nature. 431 (7005): 221–5. Bibcode:2004Natur.431..221H. doi:10.1038/nature02914. PMID 15329733. S2CID 4332050.
^ "Entrez Gene: SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159210 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006058 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10419521-5] Schmidt AE; Miller T; Schmidt SL; Shiekhattar R; Shilatifard A (Aug 1999). "Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II". J Biol Chem. 274 (31): 21981–5. doi:10.1074/jbc.274.31.21981. PMID 10419521.

[pmid15329733-6] Hierro A; Sun J; Rusnak AS; Kim J; Prag G; Emr SD; Hurley JH (Sep 2004). "Structure of the ESCRT-II endosomal trafficking complex". Nature. 431 (7005): 221–5. Bibcode:2004Natur.431..221H. doi:10.1038/nature02914. PMID 15329733. S2CID 4332050.

[entrez-7] "Entrez Gene: SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)".

SNF8 information

and 3 Related for: SNF8 information

SNF8

Myocardial infarction

Chromosome 17