Enzymes that remove methyl (CH3-) groups from nucleic acids
Demethylases are enzymes that remove methyl (CH3) groups from nucleic acids, proteins (particularly histones), and other molecules. Demethylases are important epigenetic proteins, as they are responsible for transcriptional regulation of the genome by controlling the methylation of DNA and histones, and by extension, the chromatin state at specific gene loci.
Demethylases are enzymes that remove methyl (CH3) groups from nucleic acids, proteins (particularly histones), and other molecules. Demethylases are important...
Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A...
Histone demethylase may refer to: Demethylase (Histone-H3)-lysine-36 demethylase This disambiguation page lists articles associated with the title Histone...
cytochrome P450 enzyme 14α-demethylase. Mammalian demethylase activity is much less sensitive to fluconazole than fungal demethylase. This inhibition prevents...
DNA oxidative demethylase (EC 1.14.11.33, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, alkB (gene)) is an enzyme with...
hypoglycaemia (low blood sugar) Miconazole inhibits the fungal enzyme 14α-sterol demethylase, resulting in a reduced production of ergosterol. In addition to its...
16. As one homolog in the AlkB family proteins, it is the first mRNA demethylase that has been identified. Certain alleles of the FTO gene appear to be...
Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene. This gene is a member of the Jumonji domain 2 (JMJD2) family...
to TBXAS1 (ThromBoXane A2 Synthase 1), and CYP51A1, lanosterol 14-α-demethylase, sometimes unofficially abbreviated to LDM according to its substrate...
conversion of lanosterol to ergosterol by inhibition of lanosterol 14α-demethylase. These compounds have a five-membered ring containing two or three nitrogen...
Lysine-specific demethylase 5B also known as histone demethylase JARID1B is a demethylase enzyme that in humans is encoded by the KDM5B gene. JARID1B...
Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene. This gene likely encodes a histone lysine demethylase. Studies of a similar...
Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B (JMJD3) gene. KDM6B was found to be expressional increased during cardiac and...
USP9Y USP9X Ubiquitin protease. DDX3Y DDX3X Helicase. UTY UTX Histone demethylase. TB4Y TB4X AZFb (none) Second AZF region on arm q. Prone to NAHR [non-allelic...
The human KDM2B gene encodes the protein lysine (K)-specific demethylase 2B. KDM2B is broadly and highly expressed in embryonic tissues (especially in...
Bomedemstat was developed to inhibit the human enzyme lysine-specific demethylase-1 (LSD1 or KDM1A EC:1.14.99.66), an oxidating enzyme that mediates demethylation...
Lysine demethylase 7A is a protein that in humans is encoded by the KDM7A gene. GRCh38: Ensembl release 89: ENSG00000006459 – Ensembl, May 2017 GRCm38:...
gene PHF8. The research found that PHF8 encodes for a histone lysine demethylase, and is involved in epigenetic regulation. The catalytic activity of...
fungal cell membrane, by inhibiting the P450 enzyme lanosterol 14-alpha demethylase. Clotrimazole may slow fungal growth or result in fungal cell death....
genetic and epigenetic level through the function of histone lysine demethylases (KDMs) and ten-eleven translocation (TET) enzymes; ordinarily TETs hydroxylate...
likely in the early stages of AML. Such mutations include in the DNA demethylase TET2 and the metabolic enzymes IDH1 and IDH2, which lead to the generation...
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