DNA oxidative demethylase (EC 1.14.11.33, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, alkB (gene)) is an enzyme with systematic name methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming).[1][2][3] This enzyme catalyses the following chemical reaction
DNA oxidative demethylase contains iron; activity is somewhat stimulated by ascorbate.
^Falnes PØ, Johansen RF, Seeberg E (September 2002). "AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli". Nature. 419 (6903): 178–82. Bibcode:2002Natur.419..178F. doi:10.1038/nature01048. PMID 12226668. S2CID 2372162.
^Yi C, Yang CG, He C (April 2009). "A non-heme iron-mediated chemical demethylation in DNA and RNA". Accounts of Chemical Research. 42 (4): 519–29. doi:10.1021/ar800178j. PMC 2920458. PMID 19852088.
^Yi C, Jia G, Hou G, Dai Q, Zhang W, Zheng G, Jian X, Yang CG, Cui Q, He C (November 2010). "Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase". Nature. 468 (7321): 330–3. Bibcode:2010Natur.468..330Y. doi:10.1038/nature09497. PMC 3058853. PMID 21068844.
and 24 Related for: DNA oxidative demethylase information
hydroxylases. Histone lysine demethylases possess a variety of domains that are responsible for histone recognition, DNA binding, methylated amino acid...
DNAoxidation is the process of oxidative damage of deoxyribonucleic acid. As described in detail by Burrows et al., 8-oxo-2'-deoxyguanosine (8-oxo-dG)...
both the transcription of DNA and its replication. LSD1 (lysine-specific demethylase 1), through a FAD-dependent oxidative reaction, specifically removes...
deficient mice reveal mABH2 as the primary oxidativedemethylase for repairing 1meA and 3meC lesions in DNA". The EMBO Journal. 25 (10): 2189–2198. doi:10...
accompany DNA repair of oxidative damage or double-strand breaks. In human cells, oxidativeDNA damage occurs about 10,000 times a day and DNA double-strand...
dehydrogenases, lipid peroxidases, P450 oxidases, and N-methyl group demethylases. Formaldehyde is catabolized by alcohol dehydrogenase ADH5 and aldehyde...
increased oxidative stress within the cell as it is a required cofactor in the production of GSH, and this oxidative stress can result in DNA damage. There...
activity of 2-oxoglutarate-dependent dioxygenases, including histone and DNAdemethylases, prolyl hydroxylases and collagen prolyl-4-hydroxylases, through competitive...
HKme, histone lysine acetylation, and DNA methylation via the action of corresponding methyltransferases, demethylases, acetylases, and deacetylases. This...
marks are generally associated with repression of DNA transcription. Identified as a histone demethylase in 2004, LSD1 demethylates H3K4me1 and H3K4me2 but...
homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. Certain alleles of the FTO gene appear to be...
accumulate base pair mutations. Additionally, sperm are stored in the highly oxidative environment of the testis, which encourages further mutation. These two...
function in a dimethylnitrosamine demethylase process in rat livers. Inhibition could happen on by interfering in demethylase conformations or by interfering...
of DNA is catalyzed by demethylases. These enzymes oxidize N-methyl groups, which occur in histones, in lysine derivatives, and in some forms of DNA. R2N-CH3...
needed] ROS cause more than 20 types of DNA damage. OxidativeDNA damage is mutagenic. In addition, repair of the DNA damage can cause epigenetic alterations...
(ESC) genes, and the activation of cell fate genes. Lysine specific demethylase 1 (KDM1A) is thought to prevent the use of enhancer regions of pluripotency...
R. P.; Lindahl, T; Sedgwick, B (2002). "Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage". Nature. 419 (6903): 174–8...
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is an enzyme that in humans is encoded by the JMJD6 gene. This gene encodes a nuclear protein...
with the endoplasmic reticulum. ROS cause more than 20 types of DNA damage. OxidativeDNA damage is mutagenic. HBx has large effects on the transcription...
genes, an increase in transcription of LSD1, a H3K4 and H3K9 demethylase, and various DNA Methyl-Transferases (DNMTs), and increased presence of miRNAs...
methyl groups to DNA are called DNA methyltransferases (DNMTs). The enzyme responsible for removal of methyl group are called DNAdemethylases. The effects...
roles. He and colleagues subsequently discovered the first RNA demethylase that oxidatively reverses N6-methyladenosine (m6A) methylation in mammalian messenger...
response to oxidative stress, IDH1 also indirectly participates in mitigating oxidative damage. In addition, IDH1 is key to β-oxidation of unsaturated...
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