Protein-coding gene in the species Homo sapiens
KDM8 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UYJ, 4AAP, 4GAZ, 4GJY, 4GJZ, 4QU1
Identifiers Aliases KDM8 , JMJD5, lysine demethylase 8External IDs OMIM: 611917; MGI: 1924285; HomoloGene: 49791; GeneCards: KDM8; OMA:KDM8 - orthologs Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 27,203,508 bp[1] End 27,221,768 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 125,043,848 bp[2] End 125,061,441 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum testicle gonad granulocyte apex of heart epithelium of colon body of pancreas prefrontal cortex mucosa of transverse colon
Top expressed in retinal pigment epithelium primitive streak cumulus cell neural layer of retina embryo morula secondary oocyte ventricular zone triceps brachii muscle Rostral migratory stream
More reference expression data
BioGPS
Gene ontology Molecular function
dioxygenase activity
chromatin binding
oxidoreductase activity
metal ion binding
histone H3-methyl-lysine-36 demethylase activity
histone demethylase activity
protein binding
peptidase activity
hydrolase activity
aminopeptidase activity
endopeptidase activity
2-oxoglutarate-dependent dioxygenase activity
methylated histone binding Cellular component
nucleus
nucleoplasm
cytosol
chromosome Biological process
regulation of transcription, DNA-templated
cell cycle
G2/M transition of mitotic cell cycle
positive regulation of transcription, DNA-templated
histone H3-K36 demethylation
transcription, DNA-templated
proteolysis
chromatin organization
protein destabilization
circadian regulation of gene expression
negative regulation of transcription, DNA-templated
rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 16: 27.2 – 27.22 Mb Chr 7: 125.04 – 125.06 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene.[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000155666 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030752 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^
"Entrez Gene: Lysine demethylase 8". Retrieved 2016-04-09 .
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