Danazol, sold as Danocrine and other brand names, is a medication used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema and other conditions.[9][2][10][11][12] It is taken by mouth.[2]
The use of danazol is limited by masculinizing side effects such as acne, excessive hair growth, and voice deepening.[2][13] Danazol has a complex mechanism of action, and is characterized as a weak androgen and anabolic steroid, a weak progestogen, a weak antigonadotropin, a weak steroidogenesis inhibitor, and a functional antiestrogen.[5][14][15][16]
Danazol was discovered in 1963 and was introduced for medical use in 1971.[14][17][18][19] Due to their improved side-effect profiles, particularly their lack of masculinizing side effects, danazol has largely been replaced by gonadotropin-releasing hormone analogues (GnRH analogues) in the treatment of endometriosis.[4]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ abcdef"Danocrine Brand of Danazol Capsules, USP" (PDF). Sanofi-Aventis U.S. LLC. U.S. Food and Drug Administration.
^Griffin JP, D'Arcy PF (17 November 1997). A Manual of Adverse Drug Interactions. Elsevier. pp. 194–. ISBN 978-0-08-052583-9.
^ abNieschlag E, Behre HM, Nieschlag S (13 January 2010). Andrology: Male Reproductive Health and Dysfunction. Springer Science & Business Media. pp. 426–428. ISBN 978-3-540-78355-8.
^ abCite error: The named reference ThomasRock2012 was invoked but never defined (see the help page).
^ abCite error: The named reference LemkeWilliams2012 was invoked but never defined (see the help page).
^Cite error: The named reference Dörwald2013 was invoked but never defined (see the help page).
^Cite error: The named reference Kurman2013 was invoked but never defined (see the help page).
^ abcdeBrayfield A, ed. (30 October 2013). "Danazol". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 1 April 2014.
^Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 345–. ISBN 978-1-4757-2085-3.
^Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 293–. ISBN 978-3-88763-075-1.
^Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 91–. ISBN 978-94-011-4439-1.
^Selak V, Farquhar C, Prentice A, Singla A (October 2007). Farquhar C (ed.). "Danazol for pelvic pain associated with endometriosis". The Cochrane Database of Systematic Reviews (4): CD000068. doi:10.1002/14651858.CD000068.pub2. hdl:2292/28213. PMID 17943735.
^ abCite error: The named reference JonesRock2015 was invoked but never defined (see the help page).
^Cite error: The named reference Lupulescu1990 was invoked but never defined (see the help page).
^Cite error: The named reference AltchekDeligdisch2003 was invoked but never defined (see the help page).
^Cite error: The named reference NeumannPotts1979 was invoked but never defined (see the help page).
^Cite error: The named reference EliasGwinup1983 was invoked but never defined (see the help page).
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Danazol, sold as Danocrine and other brand names, is a medication used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema...
well fitting bra may also help. In those with severe pain tamoxifen or danazol may be used. About 70% of women have breast pain at some point in time...
immunosuppressive drugs (e.g. ciclosporin, mycophenolate mofetil, vincristine and danazol) are subsequently used, or combinations of these. The off-label use of...
placebo, but were not more effective than danazol or intrauterine progestogen, and had more side effects than danazol. A 2018 Swedish systematic review found...
feedback on the HPG axis), as well as steroid synthesis inhibitors such as danazol and gestrinone. Since progestins have relatively little effect on sexual...
(1979). Danazol Treatment of Endometriosis: Long-term Follow Up. Fertility and Sterility, 32, 518-520. Greenblatt, R., & Ben-Nunn, I. (1980). Danazol in the...
1%): cystitis weight gain Vomiting Hyperglycemic action may be caused by danazol, chlorpromazine, glucocorticoids, progestogens, or β-2 agonists. Its hypoglycemic...
Wong E, Eftekhari N, Greaves MW, Ward AM (1987). "Beneficial effects of danazol on symptoms and laboratory changes in cholinergic urticaria". The British...
using a well fitting bra, and pain medication, if needed. Occasionally danazol or tamoxifen may be used for pain. It is estimated that up to 60% of women...
treatment of endometriosis. It is described as similar in action and effect to danazol, which is also used in the treatment of endometriosis, but is reported...
Future attacks of HAE can be prevented by the use of androgens such as danazol, oxandrolone or methyltestosterone. These agents increase the level of...
produce progesterone and keep levels of progesterone high during pregnancy. Danazol was described as a luteolytic agent. Cloprostenol is another example of...
Clinical trial number NCT04173494 for "A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Patients (MOMENTUM)" at ClinicalTrials...
"Successful treatment of D-penicillamine-induced breast gigantism with danazol". British Medical Journal. 282 (6261): 362–363. doi:10.1136/bmj.282.6261...
isoxazole-derivative drug. Examples of AAS containing the isoxazole ring include danazol and androisoxazole. A number of pesticides are isoxazoles. Oxazole, an...
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