Protein-coding gene in humans
DYNLL1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CMI, 3ZKE, 3ZKF, 1F95, 1F3C, 1F96
Identifiers Aliases DYNLL1 , DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1, dynein light chain LC8-type 1External IDs OMIM: 601562; MGI: 1861457; HomoloGene: 133063; GeneCards: DYNLL1; OMA:DYNLL1 - orthologs Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 120,469,850 bp[1] End 120,498,493 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 115,435,169 bp[2] End 115,439,058 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex frontal pole gingival epithelium cingulate gyrus anterior cingulate cortex Brodmann area 9 bronchial epithelial cell right testis Brodmann area 10 right frontal lobe
Top expressed in medial ganglionic eminence endocardial cushion dentate gyrus of hippocampal formation granule cell maxillary prominence condyle mandibular prominence spermatid hair follicle seminiferous tubule abdominal wall
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
protein domain specific binding
protein C-terminus binding
protein binding
cytoskeletal motor activity
cytoskeletal protein binding
plus-end-directed microtubule motor activity
dynein intermediate chain binding
dynein light intermediate chain binding
enzyme binding
nitric-oxide synthase regulator activity
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding
Cellular component
cytoplasm
cytosol
centrosome
membrane
plasma membrane
microtubule associated complex
ciliary tip
mitochondrion
dynein complex
COP9 signalosome
mitotic spindle
microtubule
cytoskeleton
extracellular exosome
nucleus
kinetochore
cytoplasmic dynein complex
cilium
tertiary granule membrane
ficolin-1-rich granule membrane
microtubule organizing center
secretory granule
axon cytoplasm
Biological process
regulation of transcription, DNA-templated
substantia nigra development
antigen processing and presentation of exogenous peptide antigen via MHC class II
transcription, DNA-templated
endoplasmic reticulum to Golgi vesicle-mediated transport
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
G2/M transition of mitotic cell cycle
microtubule-based process
intraciliary retrograde transport
viral process
negative regulation of phosphorylation
macroautophagy
apoptotic process
intraciliary transport involved in cilium assembly
neutrophil degranulation
motile cilium assembly
ciliary basal body-plasma membrane docking
positive regulation of non-motile cilium assembly
transport along microtubule
cilium assembly
sister chromatid cohesion
regulation of G2/M transition of mitotic cell cycle
transport
spermatid development
positive regulation of insulin secretion involved in cellular response to glucose stimulus
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_003746 NM_001037494 NM_001037495
RefSeq (protein) NP_001032583 NP_001032584 NP_003737
Location (UCSC) Chr 12: 120.47 – 120.5 Mb Chr 5: 115.44 – 115.44 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Dynein light chain 1, cytoplasmic is a protein that in humans is encoded by the DYNLL1 gene.[5] [6] [7] [8]
^ a b c GRCh38: Ensembl release 89: ENSG00000088986 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009013 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Dick T, Ray K, Salz HK, Chia W (May 1996). "Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster". Molecular and Cellular Biology . 16 (5): 1966–77. doi:10.1128/mcb.16.5.1966. PMC 231184 . PMID 8628263.
^ Jaffrey SR, Snyder SH (Nov 1996). "PIN: an associated protein inhibitor of neuronal nitric oxide synthase". Science . 274 (5288): 774–7. Bibcode:1996Sci...274..774J. doi:10.1126/science.274.5288.774. PMID 8864115. S2CID 46494691.
^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". The Journal of Cell Biology . 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247 . PMID 16260502.
^ "Entrez Gene: DYNLL1 dynein, light chain, LC8-type 1".
Last Update: 2023-10-28T20:06:45Z
light chain 1, cytoplasmic is a protein that in humans is encoded by the DYNLL1 gene. Cytoplasmic dyneins are large enzyme complexes with a molecular mass...
Word Count : 1545
Last Update: 2024-04-20T07:37:29Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 2154
Last Update: 2024-02-22T06:58:08Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 7838
Last Update: 2024-06-23T10:31:28Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 3016
Last Update: 2024-05-27T06:34:30Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 5121
Last Update: 2024-04-25T14:29:26Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 3168
Last Update: 2024-04-03T19:42:49Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 2529
Last Update: 2024-06-07T15:40:27Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 3300
Last Update: 2024-06-10T06:39:34Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 4896
Last Update: 2024-06-02T00:07:56Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 4670
Last Update: 2024-05-06T01:48:50Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 3225
Last Update: 2024-06-01T09:00:39Z
the P protein from Rabies lyssavirus to the dynein light chain protein DYNLL1 has been shown. P also acts as an interferon antagonist, thus decreasing...
Word Count : 4265
Last Update: 2023-08-31T18:37:41Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 346
Last Update: 2024-06-15T17:16:37Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 2785
Last Update: 2024-03-10T09:37:14Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 779
Last Update: 2024-01-31T13:06:08Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 2198
Last Update: 2024-04-19T20:38:51Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 631
Last Update: 2024-06-14T22:55:56Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 3650
Last Update: 2024-05-06T03:07:45Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 1136
Last Update: 2024-06-15T05:32:19Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 3393
Last Update: 2024-02-22T07:11:18Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 1601
Last Update: 2023-08-31T11:02:28Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 2579
Last Update: 2023-10-15T18:04:10Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 1711
Last Update: 2024-04-26T06:22:51Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 6277
Last Update: 2023-10-04T03:48:48Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 73
Last Update: 2024-04-25T00:04:14Z
cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Microtubule organising proteins CAMSAP1...
Word Count : 4235