DNM1 information

DNM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DYN, 2DYN, 2X2E, 2X2F, 3SNH, 3ZYC, 3ZYS, 4UUD, 4UUK, 5D3Q
Identifiers
Aliases	DNM1, Dynamin-1, DNM, EIEE31, dynamin 1, DEE31
External IDs	OMIM: 602377; MGI: 107384; HomoloGene: 123905; GeneCards: DNM1; OMA:DNM1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,255,248 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,243,350 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; Brodmann area 10; ; middle temporal gyrus; ; superior frontal gyrus; ; right frontal lobe; ; frontal pole; ; paraflocculus of cerebellum; ; parietal lobe; ; Brodmann area 46; ; postcentral gyrus;
	Top expressed in
	CA3 field; ; entorhinal cortex; ; perirhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; cingulate gyrus; ; cerebellar cortex; ; central gray substance of midbrain; ; pontine nuclei; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein dimerization activity; GTP binding; protein binding; hydrolase activity; protein kinase binding; microtubule binding; RNA binding; GTPase activity; protein C-terminus binding; D2 dopamine receptor binding; protein-containing complex binding; nitric-oxide synthase binding; identical protein binding; SH3 domain binding;
Cellular component	cytoplasm; photoreceptor inner segment; myelin sheath; synapse; membrane coat; microtubule; cytoskeleton; extracellular exosome; mitochondrial membranes; Golgi apparatus; plasma membrane; synaptic vesicle; varicosity; nucleus; nucleoplasm; postsynaptic density; membrane; axon; cytoplasmic vesicle; protein-containing complex; dendritic spine; dendritic spine head; postsynaptic membrane; photoreceptor ribbon synapse; presynaptic endocytic zone membrane; postsynaptic endocytic zone membrane; glutamatergic synapse;
Biological process	endocytosis; ephrin receptor signaling pathway; adult locomotory behavior; synaptic transmission, GABAergic; toxin transport; hearing; protein tetramerization; endosome organization; clathrin-dependent endocytosis; mitochondrial fission; dynamin family protein polymerization involved in mitochondrial fission; membrane fusion; synaptic vesicle budding from presynaptic endocytic zone membrane; G protein-coupled receptor internalization; receptor-mediated endocytosis; receptor internalization; positive regulation of synaptic vesicle recycling; synaptic vesicle endocytosis; regulation of synapse structure or activity; modulation of chemical synaptic transmission; postsynaptic neurotransmitter receptor internalization; regulation of synaptic vesicle endocytosis; positive regulation of synaptic vesicle endocytosis; response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	1759
	13429
	ENSG00000106976
	ENSMUSG00000026825
	Q05193
	P39053
NM_001005336; NM_001288737; NM_001288738; NM_001288739; NM_004408;
	NM_001374269
	NM_001301737; NM_010065; NM_001368679
NP_001005336; NP_001275666; NP_001275667; NP_001275668; NP_004399;
	NP_001361198
	NP_001288666; NP_034195; NP_001355608
	Wikidata
View/Edit Human	View/Edit Mouse

Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106976 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026825 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Obar RA, Collins CA, Hammarback JA, Shpetner HS, Vallee RB (October 1990). "Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins". Nature. 347 (6290): 256–61. Bibcode:1990Natur.347..256O. doi:10.1038/347256a0. PMID 2144893. S2CID 4264539.
^ Newman-Smith ED, Shurland DL, van der Bliek AM (July 1997). "Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis". Genomics. 41 (2): 286–9. doi:10.1006/geno.1996.4596. PMID 9143509.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106976 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026825 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2144893-5] Obar RA, Collins CA, Hammarback JA, Shpetner HS, Vallee RB (October 1990). "Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins". Nature. 347 (6290): 256–61. Bibcode:1990Natur.347..256O. doi:10.1038/347256a0. PMID 2144893. S2CID 4264539.

[pmid9143509-6] Newman-Smith ED, Shurland DL, van der Bliek AM (July 1997). "Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis". Genomics. 41 (2): 286–9. doi:10.1006/geno.1996.4596. PMID 9143509.

DNM1 information

and 27 Related for: DNM1 information

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Microfilament

SNARE protein

Intermediate filament

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Pleckstrin homology domain

Microtubule

Dystrophin

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KIF18B

Divisome