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DISC2 information


DISC2
Identifiers
AliasesDISC2, DISC1-AS1, DISC1OS, NCRNA00015, disrupted in schizophrenia 2 (non-protein coding), disrupted in schizophrenia 2
External IDsOMIM: 606271; GeneCards: DISC2; OMA:DISC2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

27184

n/a

Ensembl

ENSG00000274121

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

In molecular biology, disrupted in schizophrenia 2 (non-protein coding), also known as DISC2, is a long non-coding RNA molecule. In humans, the DISC2 gene that produces the DISC2 RNA molecule is located on chromosome 1, at the breakpoint associated with the chromosomal translocation found in Schizophrenia.[2] It is antisense to the DISC1 gene and may regulate the expression of DISC1.[2][3] DISC2 may also contribute to other psychiatric disorders.[3][4]

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ a b Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, St Clair DM, Muir WJ, Blackwood DH, Porteous DJ (May 2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Human Molecular Genetics. 9 (9): 1415–1423. doi:10.1093/hmg/9.9.1415. hdl:20.500.11820/debc2b54-6e20-425f-9eab-dcd0c136cc98. PMID 10814723.
  3. ^ a b Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine. 36 (5): 367–378. doi:10.1080/07853890410033603. PMID 15478311. S2CID 36081296.
  4. ^ Hodgkinson CA, Goldman D, Jaeger J, Persaud S, Kane JM, Lipsky RH, Malhotra AK (Nov 2004). "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder". American Journal of Human Genetics. 75 (5): 862–872. doi:10.1086/425586. PMC 1182115. PMID 15386212.

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