Cytochrome P450 omega hydroxylases, also termed cytochrome P450 ω-hydroxylases, CYP450 omega hydroxylases, CYP450 ω-hydroxylases, CYP omega hydroxylase, CYP ω-hydroxylases, fatty acid omega hydroxylases, cytochrome P450 monooxygenases, and fatty acid monooxygenases, are a set of cytochrome P450-containing enzymes that catalyze the addition of a hydroxyl residue to a fatty acid substrate. The CYP omega hydroxylases are often referred to as monoxygenases; however, the monooxygenases are CYP450 enzymes that add a hydroxyl group to a wide range of xenobiotic (e.g. drugs, industrial toxins) and naturally occurring endobiotic (e.g. cholesterol) substrates, most of which are not fatty acids. The CYP450 omega hydroxylases are accordingly better viewed as a subset of monooxygenases that have the ability to hydroxylate fatty acids. While once regarded as functioning mainly in the catabolism of dietary fatty acids, the omega oxygenases are now considered critical in the production or break-down of fatty acid-derived mediators which are made by cells and act within their cells of origin as autocrine signaling agents or on nearby cells as paracrine signaling agents to regulate various functions such as blood pressure control and inflammation.[1]
^Ni KD, Liu JY (2021). "The Functions of Cytochrome P450 ω-hydroxylases and the Associated Eicosanoids in Inflammation-Related Diseases". Front Pharmacol. 12: 716801. doi:10.3389/fphar.2021.716801. PMC 8476763. PMID 34594219.
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molecules. In humans, a subset of CytochromeP450 (CYP450) microsome-bound ω-hydroxylases (termed CytochromeP450omegahydroxylases) metabolize arachidonic acid...
CytochromeP450 4F2 is a protein that in humans is encoded by the CYP4F2 gene. This protein is an enzyme, a type of protein that catalyzes (helps speed...
CytochromeP450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the CYP1A1 gene. The protein is a member of the cytochrome...
CytochromeP450 4F3, also leukotriene-B(4) omega-hydroxylase 2, is an enzyme that in humans is encoded by the CYP4F3 gene. CYP4F3 encodes two distinct...
CytochromeP450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in...
CytochromeP450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by oxidation, of both...
NAD(P)H. One important subset of the monooxygenases, the cytochromeP450omegahydroxylases, is used by cells to metabolize arachidonic acid (i.e. eicosatetraenoic...
Cytochrome P4502C8 (CYP2C8) is a member of the cytochromeP450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body. Cytochrome...
CytochromeP450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochromeP450 mixed-function oxidase system, which is involved in the metabolism...
CYP4A22 (cytochromeP450, family 4, subfamily A, polypeptide 22) also known as fatty acid omega-hydroxylase is a protein which in humans is encoded by...
CytochromeP450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochromeP450 mixed-function oxidase system...
CytochromeP450 4A11 is a protein that in humans is codified by the CYP4A11 gene. This gene encodes a member of the cytochromeP450 superfamily of enzymes...
plants synthesize cutin. Omega hydroxy fatty acids also occur in animals. CytochromeP450 (CYP450) microsome ω-hydroxylases such as CYP4A11, CYP4A22,...
CytochromeP450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene. CYP1B1 belongs to the cytochromeP450 superfamily of enzymes. The cytochrome...
proteins, is a CytochromeP450omegahydroxylase, i.e. an enzyme that metabolizes fatty acids to their omega hydroxyl derivatives (see Omega oxidation)....
for Biotechnology Information. Hardwick JP (June 2008). "CytochromeP450omegahydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases"...
CytochromeP450 2J2 (CYP2J2) is a protein that in humans is encoded by the CYP2J2 gene. CYP2J2 is a member of the cytochromeP450 superfamily of enzymes...
19Z-docosahexaenoic acid) is an omega oxidation product of PD1 probably formed in cells by the action of an unidentified CytochromeP450omegahydroxylase (see specialized...
M047357. PMC 4031946. PMID 24634501. Hardwick, J. P. (2008). "CytochromeP450omegahydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases"...
metabolism, linoleic acid metabolism, and metabolism of xenobiotics by cytochromep450. It employs one cofactor, heme. As of late 2007, 53 structures have...
AA. LA is also converted by various lipoxygenases, cyclooxygenases, cytochromeP450 enzymes (the CYP monooxygenases), and non-enzymatic autoxidation mechanisms...
CytochromeP450 2C18 is a protein that in humans is encoded by the CYP2C18 gene. This gene encodes a member of the cytochromeP450 superfamily of enzymes...
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