oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
metal ion binding
arachidonic acid 14,15-epoxygenase activity
heme binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
arachidonic acid 11,12-epoxygenase activity
oxidoreductase activity
aromatase activity
linoleic acid epoxygenase activity
monooxygenase activity
arachidonic acid epoxygenase activity
steroid hydroxylase activity
Cellular component
organelle membrane
endoplasmic reticulum membrane
membrane
intracellular membrane-bounded organelle
endoplasmic reticulum
extracellular exosome
cytoplasm
Biological process
linoleic acid metabolic process
regulation of heart contraction
epoxygenase P450 pathway
icosanoid metabolic process
xenobiotic metabolic process
organic acid metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1573
13110
Ensembl
ENSG00000134716
ENSMUSG00000052914
UniProt
P51589
O54750
RefSeq (mRNA)
n/a
NM_010008
RefSeq (protein)
NP_000766
NP_034138
Location (UCSC)
n/a
Chr 4: 96.4 – 96.44 Mb
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
Cytochrome P450 2J2 (CYP2J2) is a protein that in humans is encoded by the CYP2J2 gene.[4][5] CYP2J2 is a member of the cytochrome P450 superfamily of enzymes. The enzymes are oxygenases which catalyze many reactions involved in the metabolism of drugs and other xenobiotics) as well as in the synthesis of cholesterol, steroids and other lipids.
^ abcGRCm38: Ensembl release 89: ENSMUSG00000052914 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ma J, Ramachandran S, Fiedorek FT, Zeldin DC (Apr 1998). "Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4". Genomics. 49 (1): 152–5. doi:10.1006/geno.1998.5235. PMID 9570962.
Cytochrome P450 2J2 (CYP2J2) is a protein that in humans is encoded by the CYP2J2 gene. CYP2J2 is a member of the cytochrome P450 superfamily of enzymes...
themselves. Some albendazole is also converted to hydroxyalbendazole, mainly by CYP2J2. For systemic parasites, albendazole acts as a prodrug, while albendazole...
within the CYP3A sub family, CYP3A4; in humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly CYP2S1 isoforms are the main producers of EETs although CYP2C9...
epoxyeicosatetraenoic acids (also termed EEQs). Along with CYP2C19, CYP2C8, CYP2C9, CYP2J2, and possibly CYP2S1 are the main producers of EETs and, very likely EEQs...
products that act as signaling molecules. It along with CYP2C8, CYP2C19, CYP2J2, and possibly CYP2S1 are the principle enzymes which metabolizes 1) arachidonic...
within the CYP3A subfamily, CYP3A4. In humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly CYP2S1 isoforms appear to be the principal epoxygenases responsible...
CYP3A4. In humans, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, CYP3A4, and CYP2S1 metabolize EPA to EEQs, in most cases forming principally...
epoxyeicosatetraenoic acids (also termed EEQs). Along with CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly CYP2S1 are the main producers of EETs and, very likely, EEQs...
epoxyeicosatetraenoic acids (also termed EEQs). While CYP2C19, CYP2C8, CYP2C9, CYP2J2, and possibly CYP2S1 are the main producers of EETs and, very likely EEQs...
more potent than the CYP450 epoxygenase (e.g. CYP2C8, CYP2C9, CYP2C19, CYP2J2, and CYP2S1)-formed epoxides of arachidonic acid (termed EETs) in decreasing...
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