CYP4F11 information

CYP4F11
Identifiers
Aliases	CYP4F11, CYPIVF11, cytochrome P450 family 4 subfamily F member 11
External IDs	OMIM: 611517; MGI: 3645508; HomoloGene: 117991; GeneCards: CYP4F11; OMA:CYP4F11 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,934,867 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	32,895,888 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gallbladder; ; mucosa of transverse colon; ; islet of Langerhans; ; Descending thoracic aorta; ; mucosa of esophagus; ; right adrenal cortex; ; corpus epididymis; ; ascending aorta; ; gastric mucosa;
	Top expressed in
	ileum; ; jejunum; ; colon; ; duodenum; ; morula; ; testicle; ; pancreas; ; blastocyst; ; placenta; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; monooxygenase activity; fatty acid binding;
Cellular component	integral component of membrane; organelle membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle;
Biological process	phylloquinone catabolic process; inflammatory response; blood coagulation; vitamin K catabolic process; menaquinone catabolic process; fatty acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	57834
	631304
	ENSG00000171903
	ENSMUSG00000090700
	Q9HBI6
	G3UW81
	NM_001128932; NM_021187
	NM_001101588; NM_001368735
	NP_001122404; NP_067010
	NP_001095058; NP_001355664
	Wikidata
View/Edit Human	View/Edit Mouse

CYP4F11 (cytochrome P450, family 4, subfamily F, polypeptide 11) is a protein that in humans is encoded by the CYP4F11 gene.^[5] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090700 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cui X, Nelson DR, Strobel HW (September 2000). "A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization". Genomics. 68 (2): 161–6. doi:10.1006/geno.2000.6276. PMID 10964514.
^ This article incorporates public domain material from "Entrez Gene: CYP4F11". Reference Sequence collection. National Center for Biotechnology Information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171903 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090700 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10964514-5] Cui X, Nelson DR, Strobel HW (September 2000). "A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization". Genomics. 68 (2): 161–6. doi:10.1006/geno.2000.6276. PMID 10964514.

[entrez-6] This article incorporates public domain material from "Entrez Gene: CYP4F11". Reference Sequence collection. National Center for Biotechnology Information.

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