oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
metal ion binding
steroid hydroxylase activity
catalytic activity
protein binding
heme binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
enzyme binding
vitamin D 24-hydroxylase activity
oxidoreductase activity
aromatase activity
oxidoreductase activity, acting on diphenols and related substances as donors
monooxygenase activity
estrogen 16-alpha-hydroxylase activity
Hsp70 protein binding
Hsp90 protein binding
Cellular component
cytoplasm
organelle membrane
endoplasmic reticulum membrane
intracellular membrane-bounded organelle
membrane
endoplasmic reticulum
mitochondrion
mitochondrial inner membrane
Biological process
response to immobilization stress
maternal process involved in parturition
response to hypoxia
9-cis-retinoic acid biosynthetic process
response to organic cyclic compound
coumarin metabolic process
vitamin D metabolic process
insecticide metabolic process
response to hyperoxia
response to antibiotic
demethylation
cellular response to organic cyclic compound
response to virus
human ageing
hepatocyte differentiation
epoxygenase P450 pathway
dibenzo-p-dioxin catabolic process
response to arsenic-containing substance
response to organic substance
positive regulation of G1/S transition of mitotic cell cycle
response to vitamin A
response to lipopolysaccharide
omega-hydroxylase P450 pathway
response to wounding
dibenzo-p-dioxin metabolic process
response to nematode
response to iron(III) ion
flavonoid metabolic process
response to food
liver development
camera-type eye development
digestive tract development
cell population proliferation
response to herbicide
porphyrin-containing compound metabolic process
ethylene metabolic process
lipid hydroxylation
steroid metabolic process
cellular response to copper ion
amine metabolic process
toxin metabolic process
response to toxic substance
regulation of lipid metabolic process
heterocycle metabolic process
hydrogen peroxide biosynthetic process
developmental process
long-chain fatty acid biosynthetic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1543
13076
Ensembl
ENSG00000140465
ENSMUSG00000032315
UniProt
P04798
P00184
RefSeq (mRNA)
NM_000499 NM_001319216 NM_001319217
NM_001136059 NM_009992
RefSeq (protein)
NP_000490 NP_001306145 NP_001306146
NP_001129531 NP_034122
Location (UCSC)
Chr 15: 74.72 – 74.73 Mb
Chr 9: 57.6 – 57.61 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein[5] that in humans is encoded by the CYP1A1 gene.[6] The protein is a member of the cytochrome P450 superfamily of enzymes.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000140465 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032315 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
^
Smith G, Stubbins MJ, Harries LW, Wolf CR (Dec 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
that in humans is encoded by the CYP1A1 gene. The protein is a member of the cytochrome P450 superfamily of enzymes. CYP1A1 is involved in phase I xenobiotic...
suggests that methysticin and the related compound dihydromethysticin have CYP1A1 inducing effects which may be responsible for their toxicity. Additionally...
relates to the activity of cytochrome P450 subclass 1A1 (CYP1A1). Seemingly, the high activity of CYP1A1 in the intestinal mucosa prevents major amounts of...
which are formed mainly by a number of cytochrome P450 liver enzymes (CYP1A1, 1A2, 2C8, 2C9). One of them is a dicarboxylic acid, the other two are hydroxylated...
CYP3A4 and, to a lesser degree, by CYP1A2 and the extrahepatic isoform CYP1A1 "Verapamil: Drug information. Lexicomp". UpToDate. Archived from the original...
Saint-John's wort, a common herbal remedy induces CYP3A4, but also inhibits CYP1A1, CYP1B1. Tobacco smoking induces CYP1A2 (example CYP1A2 substrates are clozapine...
Sultan I oxidation were also demonstrated with human CYP enzymes, with CYP1A1 being the major enzyme involved in the oxidation of Sudan I in human tissues...
(0–20%) with negligible contributions from the less abundant enzymes CYP3A5, CYP1A1, and CYP3A4. 4-hydroxyclonidine, the main metabolite of clonidine, is also...
variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, among others. The 308 G/A single nucleotide polymorphism variation...
species that may independently damage DNA. Enzymes in the cytochrome family (CYP1A1, CYP1A2, CYP1B1) metabolize PAHs to diol epoxides. PAH exposure can increase...
the induction of cytochrome P450, family 1, subfamily A, polypeptide 1 (Cyp1a1) resultant from TCDD exposure, which was determined to be directly related...
CYP1A1 and CYP1A2, CYP1B1 was not identified and sequenced until 1994. Nucleic and amino acid analysis showed approximately 40% identity with CYP1A1....
Estrogens are metabolized via hydroxylation by cytochrome P450 enzymes such as CYP1A1 and CYP3A4 and via conjugation by estrogen sulfotransferases (sulfation)...
Ciolino, H. P.; Yeh, G. C. (1999). "The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor". British...
protopine and allocryptopine. Both protopine and allocryptopine increased CYP1A1 and CYP1A2 mRNA levels in human hepatocyte cells. The use of products containing...
Schunck WH, Roots I (2001). "Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/insect...
a compound used as the substrate in the measurement of cytochrome P450 (CYP1A1) induction using the ethoxyresorufin-O-deethylase (EROD) assay system in...
products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. Similar to delta-9-THC, a majority of CBD is...
correlated with elevated levels of expression of selected cytochrome P450s (CYP1A1/1A2, 2B1/2B2, 2E1) in PC12 cells exposed to monocrotophos (10−5 M). NIOSH...
CYP3A4 and, to a lesser degree, by CYP1A2 and the extrahepatic isoform CYP1A1 "Cyclobenzaprine". DrugBank. Archived from the original on 27 October 2018...
humans, the cytochrome P450 oxidases are thought to include CYP3A4 and CYP1A1, while those in the rats are thought to be CYP2C6 and CYP2A1. Oxidation...
Zhang CM, Ma XM, Wei WG, Zhang P, Bai ZP (April 2008). "Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with...
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