oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
metal ion binding
monooxygenase activity
heme binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
enzyme binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
steroid hydroxylase activity
Hsp70 protein binding
Hsp90 protein binding
Cellular component
organelle membrane
endoplasmic reticulum membrane
intracellular membrane-bounded organelle
membrane
intrinsic component of endoplasmic reticulum membrane
Golgi membrane
endoplasmic reticulum
mitochondrion
cytoplasm
mitochondrial inner membrane
Biological process
steroid metabolic process
epoxygenase P450 pathway
response to ozone
heterocycle metabolic process
response to organonitrogen compound
monoterpenoid metabolic process
xenobiotic metabolic process
response to ethanol
triglyceride metabolic process
carbon tetrachloride metabolic process
halogenated hydrocarbon metabolic process
benzene metabolic process
long-chain fatty acid biosynthetic process
response to bacterium
organic acid metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1571
13106
Ensembl
ENSG00000130649
ENSMUSG00000025479
UniProt
P05181
Q05421
RefSeq (mRNA)
NM_000773
NM_021282
RefSeq (protein)
NP_000764
NP_067257
Location (UCSC)
Chr 10: 133.52 – 133.56 Mb
Chr 7: 140.34 – 140.35 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown of foreign compounds in mammals.[5]
While CYP2E1 itself carries out a relatively low number of these reactions (~4% of known P450-mediated drug oxidations), it and related enzymes CYP1A2 and CYP3A4 are responsible for the breakdown of many toxic environmental chemicals and carcinogens that enter the body, in addition to basic metabolic reactions such as fatty acid oxidations.[6]
CYP2E1 protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000130649 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025479 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lewis DF, Lake BG, Bird MG, Loizou GD, Dickins M, Goldfarb PS (Feb 2003). "Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme-substrate and enzyme-inhibitor interactions". Toxicology in Vitro. 17 (1): 93–105. doi:10.1016/s0887-2333(02)00098-x. PMID 12537967.
^Rendic S, Di Carlo FJ (1997). "Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors". Drug Metabolism Reviews. 29 (1–2): 413–580. doi:10.3109/03602539709037591. PMID 9187528.
^ This article incorporates public domain material from "CYP2E1 cytochrome P450 family 2 subfamily E member 1 [ Homo sapiens (human) ]". Reference Sequence collection. National Center for Biotechnology Information.
Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism...
requires the CYP2E1 enzyme, part of the cytochrome P450 family of enzymes, to convert ethanol to acetaldehyde. Ethanol’s affinity for CYP2E1 is lower than...
the name when referring to the gene. For example, CYP2E1 is the gene that encodes the enzyme CYP2E1—one of the enzymes involved in paracetamol (acetaminophen)...
other plants in the environment. By inhibiting the cytochrome P450 enzyme CYP2E1, compounds in watercress may alter drug metabolism in individuals on certain...
reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism". Future Journal of Pharmaceutical Sciences. 9 (1)....
P450 2E1 (CYP2E1), quinine oxidoreductase (NQ01 or DT-diaphorase or NAD(P)H dehydrogenase (quinone 1)), GSH, and myeloperoxidase (MPO). CYP2E1 is involved...
is formed from it by the cytochrome P450 system (specifically, CYP1A2, CYP2E1, and CYP3A4). Used in cancer metastasis research as a blocker of E-selectin...
subsequently into methyluric acid. Important enzymes include CYP1A2 and CYP2E1. The elimination half life of theobromine is between 6 and 8 hours. Unlike...
specifically mediated by the cytochrome P450 enzyme CYP2E1, is another major route of ethanol metabolism. CYP2E1 is predominantly active at higher concentrations...
metabolic pathway (5–15%) of oxidation by cytochrome P450 enzymes, mainly by CYP2E1, forms a toxic metabolite known as NAPQI (N-acetyl-p-benzoquinone imine)...
byproduct of the distillery industry. Acetone can then be metabolized either by CYP2E1 via methylglyoxal to D-lactate and pyruvate, and ultimately glucose/energy...
cimetidine is an inhibitor of the P450 enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4. By reducing the metabolism of drugs through these enzymes, cimetidine...
involved in the N-dealkylation of domperidone, while CYP3A4, CYP1A2, and CYP2E1 are involved in its aromatic hydroxylation. All of the metabolites of domperidone...
playing the most significant role in zopiclone metabolism are CYP3A4 and CYP2E1. In addition, about 50% of the administered dose is decarboxylated and excreted...
cells. Alcohol is metabolized to acetaldehyde in the liver via the enzymes CYP2E1 and aldehyde dehydrogenase. Acetaldehyde forms reactive oxygen species in...
acts on chloride ion channels.[citation needed] Clomethiazole is a potent CYP2E1 enzyme inhibitor which slows down the metabolism of ethanol, hence its use...
CYP1A2 and CYP2C19, an inhibitor of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A, and an inducer of CYP1A2 and CYP3A4. A literature survey reveals...
metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1) into NAPQI, which is extremely toxic to liver tissue, as well as being...
CYP1A2, CYP2B6, CYP2E1, CYP2C8, and CYP1A1. The first four seem to be involved in the hydroxylation of toluene to benzyl alcohol. CYP2E1 seems to be the...
paracetamol toxicity. Chronic excessive alcohol consumption can induce CYP2E1, thus increasing the potential toxicity of paracetamol. In one study of...
medications. In human volunteers, in vivo inhibition includes CYP1A2 and CYP2E1 through use of probe drugs to measure inhibition. Its anxiolytic and hepatotoxicity...
histologically; the detoxifying zone III cells have the highest concentration of CYP2E1 and thus are most sensitive to NAPQI production in acetaminophen toxicity...
weakly bound to plasma protein. Cytochrome P450 (CYP) isozymes CYP3A4 and CYP2E1 are involved in the biotransformation of eszopiclone; thus, drugs that induce...
because it lacks the ability to interfere with the cytochrome enzymes CYP1A2, CYP2E1 and CYP3A4, thus preventing significant interaction with other drugs metabolized...
Global Information
This article incorporates public domain material from "CYP2E1 cytochrome P450 family 2 subfamily E member 1 [ Homo sapiens (human) ]". Reference Sequence collection. National Center for Biotechnology Information.
