CYP4F22 information

CYP4F22
Identifiers
Aliases	CYP4F22, ARCI5, INLNE, LI3, cytochrome P450 family 4 subfamily F member 22
External IDs	OMIM: 611495; MGI: 2445210; HomoloGene: 69814; GeneCards: CYP4F22; OMA:CYP4F22 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,552,317 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	32,712,294 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of leg; ; skin of abdomen; ; vulva; ; human penis; ; gonad; ; skin of thigh; ; gums; ; granulocyte; ; gingival epithelium;
	Top expressed in
	lip; ; esophagus; ; spermatid; ; skin of external ear; ; primary oocyte; ; skin of abdomen; ; seminiferous tubule; ; zygote; ; skin of back; ; lumbar spinal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; oxidoreductase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; monooxygenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle;
Biological process	icosanoid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	126410
	320997
	ENSG00000171954
	ENSMUSG00000061126
	Q6NT55
	Q8BGU0
	NM_173483
	NM_177307
	NP_775754
	NP_796281
	Wikidata
View/Edit Human	View/Edit Mouse

CYP4F22 (cytochrome P450, family 4, subfamily F, polypeptide 22) is a protein that in humans is encoded by the CYP4F22 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171954 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061126 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lefèvre C, Bouadjar B, Ferrand V, Tadini G, Mégarbané A, Lathrop M, Prud'homme JF, Fischer J (March 2006). "Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3". Hum. Mol. Genet. 15 (5): 767–76. doi:10.1093/hmg/ddi491. PMID 16436457.
^ This article incorporates public domain material from "Entrez Gene: CYP4F22". Reference Sequence collection. National Center for Biotechnology Information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171954 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061126 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16436457-5] Lefèvre C, Bouadjar B, Ferrand V, Tadini G, Mégarbané A, Lathrop M, Prud'homme JF, Fischer J (March 2006). "Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3". Hum. Mol. Genet. 15 (5): 767–76. doi:10.1093/hmg/ddi491. PMID 16436457.

[entrez_2532-6] This article incorporates public domain material from "Entrez Gene: CYP4F22". Reference Sequence collection. National Center for Biotechnology Information.

CYP4F22 information

and 5 Related for: CYP4F22 information

CYP4F22

Lamellar ichthyosis

Ichthyosis

Cytochrome P450 omega hydroxylase

List of OMIM disorder codes