Blood film with a striking absence of neutrophils, leaving only red blood cells and platelets.
Specialty
Hematology
Symptoms
Fever, malaise, inflammation and infection of oral mucosa, respiratory tract, digestive tract, skin, and abdominal pain[1]
Usual onset
Infancy[1]
Causes
Mutation in ELANE gene[1]
Diagnostic method
Blood test, genetic testing[1]
Treatment
G-CSF[1]
Medication
Filgrastim[1]
Frequency
1 in million (2018)[1]
Cyclic neutropenia (CyN) is a rare hematologic disorder and form of congenital neutropenia that tends to occur approximately every three weeks and lasting for few days at a time due to changing rates of neutrophil production by the bone marrow. It causes a temporary condition with a low absolute neutrophil count and because the neutrophils make up the majority of circulating white blood cells it places the body at severe risk of inflammation and infection. In comparison to severe congenital neutropenia, it responds well to treatment with granulocyte colony-stimulating factor (filgrastim), which increases the neutrophil count, shortens the cycle length, as well decreases the severity and frequency of infections.
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Cyclicneutropenia (CyN) is a rare hematologic disorder and form of congenital neutropenia that tends to occur approximately every three weeks and lasting...
(neutropenic sepsis). Neutropenia can be divided into congenital and acquired, with severe congenital neutropenia (SCN) and cyclicneutropenia (CyN) being autosomal...
elastase; the main result is emphysema. The rare disease cyclicneutropenia (also called "cyclic hematopoeiesis") is an autosomal dominant genetic disorder...
systemic immuno-dysregulation, e.g. cyclicneutropenia and human immunodeficiency virus infection. In cyclicneutropenia, more severe oral ulceration occurs...
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there is no cure for this disease. CyclicNeutropenia: CN is also known as Gray Collie Syndrome. CyclicNeutropenia is a disease that affects the neutrophils...
Yersinia. Mutations in this gene are associated with cyclicneutropenia (CyN) and severe congenital neutropenia (SCN). At least 95 disease-causing mutations in...
from affected dogs. Collies may have a genetic disease, named canine cyclicneutropenia, or grey collie syndrome. This is a stem cell disorder. Puppies with...
Rosai-Dorfman disease Castleman disease Sarcoidosis Lupus erythematosus Cyclicneutropenia Orofacial granulomatosis In possible malignancy, it is routine to...
Conditions that can cause early loss of teeth e.g. Kostmann's disease, cyclicneutropenia, Chediak-Hegashi syndrome, histiocytosis X, Papillon-Lefevre syndrome...
syndrome including periodic fever, benign paroxysmal peritonitis, cyclicneutropenia and intermittent arthralgia". Journal of the American Medical Association...
include acquired neutropenia, leukemias and others. Genetic disorders potentially associated include familial and cyclicneutropenia, Down syndrome, leukocyte...
granulocyte counts are low. Associated with genetic disorders Familial and cyclicneutropenia Down syndrome Leukocyte adhesion deficiency disorder Papillon–Lefèvre...
to the use of cyclophosphamide include lactation, active infection, neutropenia or bladder toxicity. Cyclophosphamide is a pregnancy category D drug...
resulting from a drop in the white blood cell count (to be specific, neutropenia, a deficiency of neutrophils). A complete blood count (CBC) with differential...
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a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides. Significant glycopeptide antibiotics...
S2CID 86786427. Klastersky, Jean A. (2014), "Prevention of Febrile Neutropenia", Febrile Neutropenia, Tarporley: Springer Healthcare Ltd., pp. 13–26, doi:10...
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