Echinocandins are a class of antifungal drugs[1] that inhibit the synthesis of β-glucan in the fungal cell wall via noncompetitive inhibition of the enzyme 1,3-β glucan synthase.[2][3] The class has been termed the "penicillin of antifungals,"[4] along with the related papulacandins, as their mechanism of action resembles that of penicillin in bacteria. β-glucans are carbohydrate polymers that are cross-linked with other fungal cell wall components, the fungal equivalent to bacterial peptidoglycan. Caspofungin, micafungin, and anidulafungin are semisynthetic echinocandin derivatives with limited clinical use due to their solubility, antifungal spectrum, and pharmacokinetic properties.[5]
^Denning, DW (June 2002). "Echinocandins: a new class of antifungal". The Journal of Antimicrobial Chemotherapy. 49 (6): 889–91. doi:10.1093/jac/dkf045. PMID 12039879.
^Morris MI, Villmann M (September 2006). "Echinocandins in the management of invasive fungal infections, part 1". American Journal of Health-System Pharmacy. 63 (18): 1693–703. doi:10.2146/ajhp050464.p1. PMID 16960253.
^Morris MI, Villmann M (October 2006). "Echinocandins in the management of invasive fungal infections, Part 2". American Journal of Health-System Pharmacy. 63 (19): 1813–20. doi:10.2146/ajhp050464.p2. PMID 16990627.
^Cite error: The named reference JenniferLong2003 was invoked but never defined (see the help page).
^Debono M, Gordee RS (1994). "Antibiotics that inhibit fungal cell wall development". Annual Review of Microbiology. 48: 471–97. doi:10.1146/annurev.mi.48.100194.002351. PMID 7826015.
Echinocandins are a class of antifungal drugs that inhibit the synthesis of β-glucan in the fungal cell wall via noncompetitive inhibition of the enzyme...
Echinocandin B, a lipopeptide, is a naturally occurring cyclic hexapeptide with a linoleoyl side chain. It belongs to a class of antifungal agents called...
Pneumocandin B0, also known as pneumocandin B0, pneumocandin B(0), and hydroxy echinocandin, is an organic chemical compound with the formula C50H80N8O17, produced...
Micafungin, sold under the brand name Mycamine, is an echinocandin antifungal medication used to treat and prevent invasive fungal infections including...
medication used for the treatment of invasive candidiasis. It is an echinocandin antifungal. Rezafungin was approved for medical use in the United States...
synthesis. Examples include butenafine, naftifine, and terbinafine. Echinocandins inhibit the creation of glucan in the fungal cell wall by inhibiting...
antifungal drugs of class echinocandins, recommended as the first method of treatment against invasive candidiasis. The three echinocandins currently licensed...
Anidulafungin (INN): 42 (trade names Eraxis, Ecalta) is a semisynthetic echinocandin used as an antifungal drug. It was previously known as LY303366. It may...
important. They represent a drug target for antifungal medications of the echinocandin class. The following are glucans (The α- and β- and numbers clarify the...
peripheral organs. For invasive disease, treatments include amphotericin B, echinocandins, or extended-spectrum triazole antifungals. In the history of fungi...
infections, including clotrimazole. In those with widespread disease, an echinocandin such as caspofungin or micafungin is used. A number of weeks of intravenous...
medication. Common anti-fungal drugs for internal infections include the echinocandin family of drugs and fluconazole. While algae are commonly not thought...
Merck & Co., Inc.. It is a member of a class of antifungals termed the echinocandins.[medical citation needed] It works by inhibiting the enzyme (1→3)-β-D-glucan...
resistant to amphotericin B; however, most isolates are susceptible to echinocandins. Treatment is complicated because C. auris is easily misidentified as...
vs non-neutropenic candidemia is treated differently. An intravenous echinocandin such as anidulafungin, caspofungin or micafungin is recommended as first-line...
ascospores. Anidulafungin is a semisynthetic lipopeptide antifungal drug of echinocandin B subclass, derived from a fermentation product of A. nidulans var. echinulatus...
increased use of echinocandins. Insufficient dosing of azoles has also led to the emergence of resistance. Observed rates of echinocandin resistance for...
Papularia sphaerosperma. It is a molecule with antifungal activity. Echinocandin Traxler, P.; Gruner, J.; Auden, J. A. (1977). "Papulacandins, a new family...
"New developments and directions in the clinical application of the echinocandins". Archives of Toxicology. 91 (4): 1613–1621. doi:10.1007/s00204-016-1916-3...
first described in 2016. It has been reported to produce asperthecin, echinocandin B1, desferritriacetylfusigen, and sterigmatocystin. In 2016, the genome...
resistant to common treatments like fluconazole. N. glabratus resistance to Echinocandin is also increasing, leaving expensive and toxic antifungal treatments...
azoles, other anti-fungal drug classes do exist such as polyenes and echinocandins.[citation needed] Conidia phialoconidia of A. fumigatus Colony in Petri...
macrolide or fluoroquinolone is chosen. If fungal infection is suspected, an echinocandin, such as caspofungin or micafungin, is chosen for people with severe...
structure to fluconazole) and caspofungin (glucan synthesis inhibitor of the echinocandin structural class). However, these drugs have not been FDA approved, and...
from Glarea lozoyensis. Strobilurin, azoxystrobin, micafungin, and echinocandins, are all extracted from fungi. Anidulafungin is a derivative of an Aspergillus...
glycosyltransferases, the nikkomycins, inhibitors of chitin synthase, and the echinocandins, inhibitors of fungal β-1,3-glucan synthases. Some glycosyltransferase...
Global Information