Receptor theory is the application of receptor models to explain drug behavior.[1] Pharmacological receptor models preceded accurate knowledge of receptors by many years.[2] John Newport Langley and Paul Ehrlich introduced the concept that receptors can mediate drug action at the beginning of the 20th century. Alfred Joseph Clark was the first to quantify drug-induced biological responses (specifically, f-mediated receptor activation). So far, nearly all of the quantitative theoretical modelling of receptor function has centred on ligand-gated ion channels and G protein-coupled receptors.[3]
^Kenakin T (2008). "What systems can and can't do". Br. J. Pharmacol. 153 (5): 841–3. doi:10.1038/sj.bjp.0707677. PMC 2267279. PMID 18204481.
^Kenakin, T. (2004). "Principles: Receptor theory in pharmacology". Trends Pharmacol Sci. 25 (4): 186–192. doi:10.1016/j.tips.2004.02.012. PMID 15063082.
^Rang HP (2006). "The receptor concept: pharmacology's big idea". Br. J. Pharmacol. 147 (S1): S9–16. doi:10.1038/sj.bjp.0706457. PMC 1760743. PMID 16402126.
Receptortheory is the application of receptor models to explain drug behavior. Pharmacological receptor models preceded accurate knowledge of receptors...
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The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline)...
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to...
shown in the figure 2). Agonist Receptor antagonist Autoreceptor Kenakin T (April 2004). "Principles: receptortheory in pharmacology". Trends in Pharmacological...
receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons. The NMDA receptor is...
of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled...
vibration theory is discussed in a popular but controversial book by Chandler Burr. The odor character is encoded in the ratio of activities of receptors tuned...
PMID 20880390. Ruffolo RR Jr (December 1982). "Review important concepts of receptortheory". Journal of Autonomic Pharmacology. 2 (4): 277–295. doi:10.1111/j...
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interactions with receptors, as ligands have been shown to interact with ligands without being in their conformation of lowest energy. While this theory of odorant...
sweetness is the multipoint attachment theory, which involves multiple binding sites between a sweetness receptor and a sweet substance. Studies indicate...
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specificity theory and the peripheral pattern theory, the gate control theory is considered to be one of the most influential theories of pain. This theory provided...
Retrieved 7 March 2018. Quirke V (January 2006). "Putting theory into practice: James Black, receptortheory and the development of the beta-blockers at ICI, 1958-1978"...
be P2Y receptors when they were cloned, when in fact they are not. Receptor (biochemistry) Purinergic signalling Membrane protein Receptortheory Abbracchio...
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by...
starting at about the end of the 19th century. The development of receptortheory at the start of the 20th century and later developments led to better...
nerve cells. Langley is known as one of the fathers of the chemical receptortheory, and as the origin of the concept of "receptive substance". Towards...
Competitive inhibition Cooperative binding Enzyme kinetics Protein dynamics Receptortheory Cooper A, Dryden DT (October 1984). "Allostery without conformational...
generally termed receptors, although in some cases the term sensor is used. The changes elicited by ligand binding (or signal sensing) in a receptor give rise...
Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three main classes of imidazoline receptor: I1 is...
Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system of vertebrates– a class of cell membrane receptors in the G protein-coupled...
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