Clortermine information

Clortermine
Clinical data
Other names	2-chloro-α,α-dimethylphenethylamine;; 2-chloro-α-methylamphetamine;; 2-chlorophentermine
Pregnancy; category	?;
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	US: Schedule III; In general: ℞ (Prescription only);
Identifiers
	IUPAC name 1-(2-chlorophenyl)-2-methylpropan-2-amine;
CAS Number	10389-73-8 ;
PubChem CID	25223;
DrugBank	DB01527 ;
ChemSpider	23558 ;
UNII	4FA88HM3IX;
KEGG	D03566 ;
ChEMBL	ChEMBL1697833 ;
CompTox Dashboard (EPA)	DTXSID0022850 ;
Chemical and physical data
Formula	C10H14ClN
Molar mass	183.68 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccccc1CC(N)(C)C;
	InChI InChI=1S/C10H14ClN/c1-10(2,12)7-8-5-3-4-6-9(8)11/h3-6H,7,12H2,1-2H3 ; Key:HXCXASJHZQXCKK-UHFFFAOYSA-N ;
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Clortermine (Voranil) was developed by Ciba in the 1960s^[1] and is an anorectic drug of the amphetamine class.^[2] It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine,^[3] and as a result it likely does not act on dopamine. Instead, it may act as a serotonin and/or norepinephrine releasing agent.^{[citation needed]}

^ US patent 3415937, "The Suppression of Appetite with 1-(o-Chlorophenyl)-2-Methyl-2-Propylamine"
^ Triggle DJ (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall / CRC. ISBN 0-412-46630-9.
^ Sannerud CA, Brady JV, Griffiths RR (1989). "Self-injection in baboons of amphetamines and related designer drugs". NIDA Research Monograph. 94: 30–42. PMID 2514366.

[1] US patent 3415937, "The Suppression of Appetite with 1-(o-Chlorophenyl)-2-Methyl-2-Propylamine"

[isbn0-412-46630-9-2] Triggle DJ (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall / CRC. ISBN 0-412-46630-9.

[pmid2514366-3] Sannerud CA, Brady JV, Griffiths RR (1989). "Self-injection in baboons of amphetamines and related designer drugs". NIDA Research Monograph. 94: 30–42. PMID 2514366.

Clortermine information

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Clortermine

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C10H14ClN

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Clinical data

Other names	2-chloro-α,α-dimethylphenethylamine; 2-chloro-α-methylamphetamine; 2-chlorophentermine
Pregnancy category	?
Routes of administration	Oral
ATC code	none
Legal status
Legal status	US: Schedule III In general: ℞ (Prescription only)
Identifiers
IUPAC name 1-(2-chlorophenyl)-2-methylpropan-2-amine
CAS Number	10389-73-8^N
PubChem CID	25223
DrugBank	DB01527^Y
ChemSpider	23558^Y
UNII	4FA88HM3IX
KEGG	D03566^Y
ChEMBL	ChEMBL1697833^N
CompTox Dashboard (EPA)	DTXSID0022850
Chemical and physical data
Formula	C₁₀H₁₄ClN
Molar mass	183.68 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1ccccc1CC(N)(C)C
InChI InChI=1S/C10H14ClN/c1-10(2,12)7-8-5-3-4-6-9(8)11/h3-6H,7,12H2,1-2H3^Y Key:HXCXASJHZQXCKK-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)