Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production.[1][7][8] It is mainly used in the treatment of heartburn and peptic ulcers.[1][8][9]
With the development of proton pump inhibitors, such as omeprazole, approved for the same indications, cimetidine is available as an over-the-counter formulation to prevent heartburn or acid indigestion, along with the other H2-receptor antagonists.[10]
Cimetidine was developed in 1971 and came into commercial use in 1977.[11][12] Cimetidine was approved in the United Kingdom in 1976,[citation needed] and was approved in the United States by the Food and Drug Administration in 1979.[13]
^ abcElks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Bibliographies. Springer. pp. 275–. ISBN 978-1-4757-2085-3.
^ abGupta A, Singh-Radcliff N (12 March 2013). Pharmacology in Anesthesia Practice. Oxford University Press. pp. 177–. ISBN 978-0-19-934399-7.
^Dowd FJ, Johnson B, Mariotti A (3 September 2016). Pharmacology and Therapeutics for Dentistry - E-Book. Elsevier Health Sciences. pp. 406–. ISBN 978-0-323-44595-5.
^ abcdefCite error: The named reference LeikinPaloucek1995 was invoked but never defined (see the help page).
^ abcProfiles of Drug Substances, Excipients and Related Methodology. Academic Press. 24 October 1984. pp. 176–. ISBN 978-0-08-086108-1.
^Cite error: The named reference VallerandSanoski2016 was invoked but never defined (see the help page).
^Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 234–. ISBN 978-3-88763-075-1.
^ abMorton I, Morton IK, Hall JM (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 77–. ISBN 978-0-7514-0499-9.
^Jacqueline B, Rosenthal L (2 December 2014). "Drugs for Peptic Ulcer Disease". Lehne's Pharmacology for Nursing Care. Elsevier Health Sciences. pp. 952–. ISBN 978-0-323-34026-7.
^Pino MA, Azer SA (March 2023). "Cimetidine". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 31334975. Bookshelf ID: NBK544255. Retrieved 6 November 2023 – via U.S. National Library of Medicine.
^Fischer J, Ganellin CR (24 August 2010). Analogue-based Drug Discovery II. John Wiley & Sons. p. 4. ISBN 978-3-527-63212-1.
^Alapi EM, Fischer J (2006). "Table of Selected Analogue Classes". In Fischer J, Ganellin CR (eds.). Analogue-based Drug Discovery. John Wiley & Sons. p. 444. ISBN 9783527607495.
^"Tagamet: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 9 November 2023.
Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. It is mainly used...
of ulcers and reflux oesophagitis than the H2 blockers ranitidine and cimetidine. H2 antagonists, which all end in "-tidine", are a type of antihistamine...
blistering are common. There is no high-quality evidence for cimetidine. However, oral cimetidine has been used as an alternative treatment for the pediatric...
progressing to bulbar paresis and respiratory paralysis.[citation needed] Cimetidine has also been reported to be effective for acute porphyric crisis and...
parietal cells, ultimately reducing acid secretion into the stomach. Unlike cimetidine, the first H2 antagonist, famotidine has a minimal effect on the cytochrome...
associated with the use of the second-generation H2 receptor antagonist cimetidine (Tagamet). Galactorrhea can also be caused by antipsychotics that cause...
praziquantel. Chloroquine also reduces its bioavailability. The drug cimetidine heightens praziquantel bioavailability. The drug's mode of action is not...
and half-life of albendazole sulfoxide's R(+) enantiomer. The antacid cimetidine heightens serum albendazole concentrations, increases the half-life of...
certain antiarrhythmics (amiodarone, mexiletine, propafenone, verapamil), cimetidine, famotidine, aciclovir, ticlopidine and oral contraceptives) is contraindicated...
of H1 antagonists, or possibly with an H2-receptor antagonist such as cimetidine. Over-the-counter vitamin C, 1000 mg daily, increases histamine degradation...
as inhibitors of the CYP3A4 enzyme such as ketoconazole, erythromycin, cimetidine, and furanocoumarin derivatives (found in grapefruit) lead to increased...
receptors. Cimetidine, for example, is notorious for antagonizing androgenic testosterone and DHT receptors at high doses. Examples include: Cimetidine Famotidine...
changes occur with a moderate inhibitor of CYP2C19 and other cytochromes cimetidine: amitriptyline level increases by about 70%, while nortriptyline decreases...
concentrations of metformin in the body. Histamine H2 receptor antagonists like cimetidine and ranitidine may reduce the efficacy of cefalexin by delaying its absorption...
in patients with special risks like heart failure. As with piroxicam, cimetidine can increase plasma levels but is unlikely to cause relevant interactions...
blockers, class I antiarrhythmic agents, ivabradine, clonidine, reserpine, cimetidine, lithium, amitriptyline Diagnosis of sinus bradycardia can be confirmed...
resolve tumors with or without surgical removal for at least 2 years. Cimetidine works by slowing tumor growth; it is a histamine blocker that maintains...
and carprofen). Gastrointestinal-protectant drugs, such as misoprostol, cimetidine, omeprazole, ranitidine, or sucralfate, are frequently included as a part...
Marshall and Ian Hislop begin a study to compare bismuth treatment with cimetidine. The study is abandoned because it is inconclusive. June: Warren and Marshall's...
hypertonic liquids, and lessened by adequate training. Ingestion of 800 mg of cimetidine two hours before running a marathon did not significantly affect the frequency...
intermediate compound in the development of the successful anti-ulcer drug cimetidine (Tagamet). After discovering that burimamide is largely inactive at physiological...
metformin and cimetidine are cleared from the body by tubular secretion, and both, particularly the cationic (positively charged) form of cimetidine, may compete...
reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine". Digestive Diseases and Sciences. 40 (11): 2469–72. doi:10.1007/bf02063257...
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