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Albendazole information


Albendazole
Clinical data
Trade namesAlbenza, Eskazole, Valbazen, Zentel, others
AHFS/Drugs.comMonograph
MedlinePlusa610019
License data
  • US DailyMed: Albendazole
Pregnancy
category
  • AU: D
Routes of
administration
By mouth
ATC code
  • P02CA03 (WHO) QP52AC11 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only (for humans; veterinary suspension and paste are both OTC)[1]
Pharmacokinetic data
Bioavailability<5%[2]
Protein binding70%[2]
MetabolismLiver[2]
Elimination half-life8-12 hours[2]
ExcretionBile duct (humans)
Kidney (ruminants)
Identifiers
CAS Number
  • 54965-21-8 checkY
PubChem CID
  • 2082
DrugBank
  • DB00518 checkY
ChemSpider
  • 1998 checkY
UNII
  • F4216019LN
KEGG
  • D00134 checkY
ChEBI
  • CHEBI:16664 checkY
ChEMBL
  • ChEMBL1483 checkY
NIAID ChemDB
  • 007895
CompTox Dashboard (EPA)
  • DTXSID0022563 Edit this at Wikidata
ECHA InfoCard100.053.995 Edit this at Wikidata
Chemical and physical data
FormulaC12H15N3O2S
Molar mass265.33 g·mol−1
3D model (JSmol)
  • Interactive image
Melting point208 to 210 °C (406 to 410 °F)
SMILES
  • CCCSc2ccc1nc(NC(=O)OC)[nH]c1c2
InChI
  • InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) checkY
  • Key:HXHWSAZORRCQMX-UHFFFAOYSA-N checkY
  (verify)

Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type.[3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.[3]

Common side effects include nausea, abdominal pain, and headache.[3] Rare but potentially serious side effects include bone marrow suppression which usually improves on discontinuing the medication. Liver inflammation has been reported and those with prior liver problems are at greater risk.[3] It is pregnancy category D in Australia, meaning it may cause harm if taken by pregnant women.[3][4]

Albendazole was developed in 1975.[5] It is on the World Health Organization's List of Essential Medicines.[6]

  1. ^ Cite error: The named reference plumb was invoked but never defined (see the help page).
  2. ^ a b c d Cite error: The named reference MSR was invoked but never defined (see the help page).
  3. ^ a b c d e "Albendazole". Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on September 23, 2015. Retrieved August 18, 2015.
  4. ^ Australian Government (March 3, 2014). "Prescribing medicines in pregnancy database". Archived from the original on April 8, 2014. Retrieved April 22, 2014.
  5. ^ Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life. John Wiley & Sons. 2014. p. 64. ISBN 9781118819593. Archived from the original on 2017-09-08.
  6. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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Albendazole

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Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. It is used for the treatment of a variety of intestinal...

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Filariasis

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outside the United States is albendazole combined with ivermectin. A combination of diethylcarbamazine and albendazole is also effective. Side effects...

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Lymphatic filariasis

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Medications usually include a combination of 2 or more anthelmintic agents: albendazole, ivermectin, and diethylcarbamazine. Efforts to prevent mosquito bites...

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Albendazole monooxygenase

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In enzymology, an albendazole monooxygenase (EC 1.14.13.32) is an enzyme that catalyzes the chemical reaction albendazole + NADPH + H+ + O2 ⇌ {\displaystyle...

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Mansonella perstans

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most antifilarial drugs, such as ivermectin, diethylcarbamazine, and albendazole are not effective. The optimal treatment for M. perstans infection remains...

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Neurocysticercosis

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epileptic therapy and a long-course medication of praziquantel (PZQ) and/or albendazole. Steroid therapy may be necessary to minimize the inflammatory reaction...

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Anthelmintic

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The drugs of choice for soil-transmitted helminths are mebendazole and albendazole; for schistosomiasis and tapeworms it is praziquantel. Many early treatments...

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Pinworm infection

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with two doses of the medications mebendazole, pyrantel pamoate, or albendazole two weeks apart. Everyone who lives with or takes care of an infected...

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Trichinosis

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Infection is typically treated with antiparasitic medication such as albendazole or mebendazole. Rapid treatment may kill adult worms and thereby stop...

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WHO Model List of Essential Medicines for Children

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Valproic acid (sodium valproate)α Albendazole Ivermectin Levamisole Mebendazole Niclosamide Praziquantel Pyrantel Albendazole Diethylcarbamazine Ivermectin...

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Grapiprant

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increased when used in conjunction with other drugs such as acetaminophen, albendazole, and alitretinoin.[citation needed] Common side effects are intestinal...

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Ascariasis

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Treatments recommended by the World Health Organization are the medications albendazole, mebendazole, levamisole, or pyrantel pamoate. Other effective agents...

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List of GSK plc products

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Duvroq (daprodustat) Dyazide (hydrochlorothiazide/triamterene) Eskazole (albendazole) Eumovate (clobetasone butyrate) Flixonase (fluticasone propionate) Flixotide...

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WHO Model List of Essential Medicines

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Levodopa/carbidopa (levodopa + carbidopa) Albendazole Ivermectin Levamisole Mebendazole Niclosamide Praziquantel Pyrantel Albendazole Diethylcarbamazine Ivermectin...

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Cysticercosis

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with neurocysticercosis may be with the medications praziquantel or albendazole. These may be required for long periods. Steroids, for anti-inflammation...

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Tubulin

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still retains some binding affinity to human and Drosophila β-tubulin, albendazole almost exclusively binds to the β-tubulin of worms and other lower eukaryotes...

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Angiostrongylus cantonensis

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antihelminthic agents (parasite-killing drugs) such as thiobendazole or albendazole effective in improving the clinical course of the illness, a number of...

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Echinococcosis

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surgical intervention, followed by medications. The medication used is albendazole, which may be needed for years. The alveolar disease may result in death...

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GSK plc

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donate 400 million albendazole tablets to the WHO each year to fight soil-transmitted helminthiasis and to provide 600 million albendazole tablets every year...

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Giardia

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tinidazole or metronidazole decreases symptoms and time to resolution. Albendazole is also used, and has an anthelmintic (anti-worm) property as well, ideal...

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Praziquantel

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tapeworm Taenia solium (though it has been judged less effective than albendazole in treatment of neurocysticercosis) In dogs and cats, whose gastrointestinal...

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Hookworm infection

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deworming are effective. Treatment is typically with the medications albendazole or mebendazole for one to three days. Iron supplements may be needed...

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Taenia solium

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reactions to the dying worms, especially if they are located in the brain. Albendazole is commonly given (along with glucocorticoids to reduce the inflammation)...

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Ivermectin

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recommends ivermectin, albendazole, or mebendazole as treatments for ascariasis. Ivermectin is sometimes added to albendazole or mebendazole for whipworm...

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Benzimidazole

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azilsartan, candesartan, and telmisartan. Anthelmintic agents such as albendazole, ciclobendazole, fenbendazole, flubendazole, mebendazole, oxfendazole...

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Trichuriasis

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on a regular basis. Treatment is with three days of the medication: albendazole, mebendazole or ivermectin. People often become infected again after...

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Hookworm

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host. In humans, treatment is by anthelminthic medications, such as albendazole and mebendazole. Treatment in animals can be done with a variety of anthelminthics...

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Ancylostoma duodenale

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the prevalence of infection, as well. A. duodenale can be treated with albendazole, mebendazole, and benzimidazoles. Pyrantel pamoate is an alternative...

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Cutaneous larva migrans

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treated in a number of different ways: Systemic (oral) agents include albendazole (trade name Albenza) and ivermectin (trade name Stromectol). Another...

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