Cilastatin inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic...
dehydropeptidase 1 when administered alone, and is almost always coadministered with cilastatin to prevent this inactivation. Common adverse drug reactions are nausea...
intermediate, and thus is co-formulated with the dehydropeptidase inhibitor cilastatin. Imipenem is available in both intravenous and intramuscular formulations...
to receive cefiderocol, or another antibacterial drug called imipenem/cilastatin. Both treatments were given intravenously for 7–14 days and neither the...
combination with meropenem or imipenem/cilastatin. Terizidone is an alternative Prothionamide is an alternative Imipenem/cilastatin is an alternative For treatment...
United States, relebactam is approved for use in the combination imipenem/cilastatin/relebactam (Recarbrio). Avibactam Papp-Wallace KM, Barnes MD, Alsop J...
to the duration of treatment according to infected sites. The imipenem/cilastatin, clindamycin, or combinations containing an inhibitor of beta-lactamases...
novel medicinal compounds. She worked to develop the compound cilastatin sodium. Cilastatin is an inhibitor of renal dehydropeptidase. Since the antibiotic...
are often severe or potentially fatal. Carbapenems (such as imipenem/cilastatin) — used as a drug of last resort for a variety of different bacterial...
Bougher BA (2002). "Comparison of ampicillin-sulbactam and imipenem-cilastatin for the treatment of Acinetobacter ventilator-associated pneumonia". Clin...
"The Effect of Different Carbapenem Antibiotics (Ertapenem, Imipenem/Cilastatin, and Meropenem) on Serum Valproic Acid Concentrations". Therapeutic Drug...
J01DH51 Imipenem and cilastatin J01DH52 Meropenem and vaborbactam J01DH55 Panipenem and betamipron J01DH56 Imipenem, cilastatin and relebactam J01DI01...
imipenem, it is stable to dehydropeptidase-1, so can be given without cilastatin. In 2016, a synthetic peptide-conjugated PMO (PPMO) was found to inhibit...
(September 2006). "Comparison of piperacillin/tazobactam and imipenem/cilastatin, both in combination with tobramycin, administered every 6 h for treatment...