Meropenem, sold under the brand name Merrem among others, is an intravenous carbapenem antibiotic used to treat a variety of bacterial infections.[2] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[2]
Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[2] Serious side effects include Clostridioides difficile infection, seizures, and allergic reactions including anaphylaxis.[2] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well.[2] Use in pregnancy appears to be safe.[2] It is in the carbapenem family of medications.[2] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[2] It is more resistant to breakdown by β-lactamase producing bacteria.[2]
Meropenem was patented in 1983.[3] It was approved for medical use in the United States in 1996.[2] It is on the World Health Organization's List of Essential Medicines.[4][5] The World Health Organization classifies meropenem as critically important for human medicine.[6]
^"Regulatory Decision Summary for Meropenem for Injection USP and Sodium Chloride Injection USP". Drug and Health Products Portal. January 4, 2024. Retrieved April 2, 2024.
^ abcdefghij"Meropenem". The American Society of Health-System Pharmacists. Archived from the original on January 20, 2011. Retrieved December 8, 2017.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 497. ISBN 978-3-527-60749-5. Archived from the original on February 27, 2024. Retrieved September 20, 2020.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^World Health Organization (2019). Critically important antimicrobials for human medicine (6th revision ed.). Geneva: World Health Organization. hdl:10665/312266. ISBN 978-92-4-151552-8.
Meropenem, sold under the brand name Merrem among others, is an intravenous carbapenem antibiotic used to treat a variety of bacterial infections. Some...
including doripenem, imipenem, and meropenem, are not recommended in this population. Doripenem, imipenem, and meropenem are recommended for high-risk community-acquired...
antibiotics as well, but seems to be most pronounced for ertapenem and meropenem. This is likely caused by several mechanisms: carbapenems inhibit transport...
size dosage of antibiotics. Meropenem is an antibiotic that is delivered into the body via injection. When produced meropenem is a crystalline antibiotic...
difficult. Treatment is typically with antibiotics such as clindamycin, meropenem, ampicillin/sulbactam, or moxifloxacin. For those with only chemical pneumonitis...
highly resistant to beta-lactamases. Examples of carbapenems include meropenem and imipenem. "Feedback for Practical 10: Antimicrobial Agents". Archived...
multiple antibiotics and may include ceftazidime, minocycline, piperacillin, meropenem, chloramphenicol, and trimethoprim/sulfamethoxazole(co-trimoxazole). Although...
the dosage of ceftazidime, meropenem, and co-trimoxazole should be lowered. Once the clinical condition improved, meropenem can be switched back to ceftazidime...
matter, nor cicatricial leukomalacia. A broad spectrum cephalosporin and meropenem are often used because of the good penetration into the central nervous...
aeruginosa is intrinsically resistant to all other penicillins. carbapenems (meropenem, imipenem, doripenem, but not ertapenem) polymyxins (polymyxin B and colistin)...
intravenous eravacycline(1.0 mg/kg every 12 hours) compared to those receiving meropenem (1g every 8 hours). The study enrolled 500 adult patients with the primary...
Merrem may refer to: Meropenem, an antibiotic initially marketed under the trade name Merrem Blasius Merrem (1761–1824), German naturalist, zoologist...
intracranial penetration are metronidazole, chloramphenicol, penicillins, and meropenem. Optimally, the selection of antimicrobial is done according to the recovered...
number of false positive results (use of antibiotics, such as imipenem, meropenem, clavulanic acid, which is sometimes combined with penicillin derivatives)...
multidrug-resistant Klebsiella species, a combination therapy with amikacin and meropenem has been suggested. Multiple drug-resistant K. pneumoniae strains have...
against Pseudomonas aeruginosa (e.g. cefepime), or carbapenems (imipenem or meropenem). A subsequent meta-analysis published in 2006 found cefepime to be associated...
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