A drug of last resort (DoLR), also known as a heroic dose,[1] is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient. Drug resistance, such as antimicrobial resistance or antineoplastic resistance, may make the first-line drug ineffective, especially in case of multidrug-resistant pathogens and tumors. Such an alternative may be outside of extant regulatory requirements or medical best practices, in which case it may be viewed as salvage therapy.
^The American Heritage Stedman's Medical Dictionary. Houghton Mifflin Company. 2004. ISBN 9780618428991.
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of a drug of last resort. Antiretroviral drugs (ARVs) are given to slow down the HIV reproduction, which in turn increases quality of life and survival...
drug of lastresort, where resistance has now been observed in Southeast Asia. As such, the needs for new antimalarial agents and new strategies of treatment...
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permitted. However, a limited number of patients have been prescribed cannabinoid pharmaceuticals as a drugoflastresort after all other treatment options...
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effects. Nevertheless, it continues to be the subject of ongoing research as a potential drugoflastresort, or a template for improved synthetic derivatives...
indirectly stimulating the release of acetylcholine, which acts on muscarinic receptors. Domperidone Drugoflastresort Serotonin-agonising laxatives Benzamide...
these findings led to vancomycin's being relegated to the position of a drugoflastresort. In 2004, Eli Lilly licensed Vancocin to ViroPharma in the U.S...
the samples were found featuring antimicrobial resistance against drugsoflastresort. "Geflügelfleischerzeugung in Europa: PHW-Gruppe unter den größten...
A drug lord, drug baron, kingpin, or lord ofdrugs is a type of crime boss in charge of a drug trafficking network, organization, or enterprise. Such lords...
myeloma as a drug of lastresort. The prototypical nuclear export inhibitor is leptomycin B, a natural product and secondary metabolite of Streptomyces bacteria...
that should be used sparingly so that it will remain effective as a drugoflastresort against potentially intractable infections. In the United States...
coli) that are resistant to the carbapenem class of antibiotics, considered the drugsoflastresort for such infections. They are resistant because they...
The war on drugs is the policy of a global campaign, led by the United States federal government, ofdrug prohibition, military aid, and military intervention...
authority to mandate manufacturer-sponsored pediatric drug trials for certain drugs as a "lastresort" if incentives and publicly funded mechanisms proved...
substance synthesized from the dried latex of the Papaver somniferum plant; it is mainly used as a recreational drug for its euphoric effects. Medical-grade...
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