peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
dermatan sulfate biosynthetic process
negative regulation of receptor signaling pathway via JAK-STAT
biological process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
633
12111
Ensembl
ENSG00000182492
ENSMUSG00000031375
UniProt
P21810
P28653
RefSeq (mRNA)
NM_001711
NM_007542
RefSeq (protein)
NP_001702
NP_031568
Location (UCSC)
Chr X: 153.49 – 153.51 Mb
Chr X: 72.53 – 72.54 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene[5] which is located on the X chromosome.
The name "biglycan" was proposed in an article by Fisher, Termine and Young in an article in the Journal of Biological Chemistry in 1989 because the proteoglycan contained two GAG chains; formerly it was known as proteoglycan-I (PG-I).[6]
^ abcGRCh38: Ensembl release 89: ENSG00000182492 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031375 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Traupe H, van den Ouweland AM, van Oost BA, Vogel W, Vetter U, Warren ST, Rocchi M, Darlison MG, Ropers HH (June 1992). "Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel". Genomics. 13 (2): 481–3. doi:10.1016/0888-7543(92)90279-2. PMID 1612609.
^Fisher LW, Termine JD, Young MF (March 1989). "Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species". J. Biol. Chem. 264 (8): 4571–6. doi:10.1016/S0021-9258(18)83781-4. PMID 2647739.
Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and...
"small leucine-rich proteoglycan family" (SLRP). These include decorin, biglycan, fibromodulin and lumican. Proteoglycans are a major component of the animal...
matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This...
BGN or bgn may refer to: Biglycan, a protein coded by the BGN gene Bulgarian lev, the currency of Bulgaria by ISO 4217 code The Western Balochi language...
present throughout the dermis and epidermis extracellular matrix, whereas biglycan and perlecan are only found in the epidermis. It harbors many mechanoreceptors...
(September 1994). "Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta". Biochem...
Global Information
