positive regulation of cytosolic calcium ion concentration
cell surface receptor signaling pathway
positive regulation of cell population proliferation
cell population proliferation
digestive tract development
signal transduction
gland development
regulation of phosphatidylinositol 3-kinase activity
G protein-coupled receptor signaling pathway
phospholipase C-activating G protein-coupled receptor signaling pathway
cholecystokinin signaling pathway
pH reduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
887
12426
Ensembl
ENSG00000110148
ENSMUSG00000030898
UniProt
P32239
P56481
RefSeq (mRNA)
NM_176875 NM_001318029 NM_001363552
NM_007627
RefSeq (protein)
NP_001304958 NP_795344 NP_001350481
NP_031653
Location (UCSC)
Chr 11: 6.26 – 6.27 Mb
Chr 7: 105.07 – 105.12 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein[5] that in humans is encoded by the CCKBR gene.[6]
This gene encodes a G protein-coupled receptor for gastrin and cholecystokinin (CCK),[7][8][9] regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000110148 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030898 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Noble F, Roques BP (Jul 1999). "CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology". Progress in Neurobiology. 58 (4): 349–79. doi:10.1016/S0301-0082(98)00090-2. PMID 10368033. S2CID 24402373.
^Pisegna JR, de Weerth A, Huppi K, Wank SA (Nov 1992). "Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization". Biochemical and Biophysical Research Communications. 189 (1): 296–303. doi:10.1016/0006-291X(92)91557-7. PMC 6719700. PMID 1280419.
^Harikumar KG, Clain J, Pinon DI, Dong M, Miller LJ (Jan 2005). "Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopy". The Journal of Biological Chemistry. 280 (2): 1044–50. doi:10.1074/jbc.M409480200. PMID 15520004.
^Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M (Mar 2004). "In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging". Journal of Nuclear Medicine. 45 (3): 485–94. PMID 15001692.
^Galés C, Poirot M, Taillefer J, Maigret B, Martinez J, Moroder L, Escrieut C, Pradayrol L, Fourmy D, Silvente-Poirot S (May 2003). "Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies". Molecular Pharmacology. 63 (5): 973–82. doi:10.1124/mol.63.5.973. PMID 12695525. S2CID 38395309.
^"Entrez Gene: CCKBR cholecystokinin B receptor".
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known as BBR1, -2, and -3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback...
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Global Information
