Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally.[2] It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.
Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it may cause panic attacks.[3]
Pentagastrin's IUPAC chemical name is "N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide".
^Martindale (1993). The extra pharmacopoeia (30th ed.). London: Pharmaceutical Press. ISBN 978-0853693000.
^Braganza JM, Herman K, Hine P, Kay G (April 1979). "The effect of pentagastrin (I.C.I. 50, 123) on peptic secretion in man". The Journal of Physiology. 289: 9–16. doi:10.1113/jphysiol.1979.sp012721. PMC 1281354. PMID 379305.
Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric...
the parietal cells (increased gastric acid production by the stomach). Pentagastrin, a synthetic gastrin, histamine, and acetylcholine are also gastric secretagogues...
Glucagon-LikePeptide 1 [7-36 Amide] Infused at Near-Physiological Concentrations on Pentagastrin-Stimulated Gastric Acid Secretion in Normal Human Subjects". Digestion...
consumption and an increase in gastrin production almost equivalent to that of pentagastrin, which may be detrimental to the patients requiring a bland diet as an...
calcitonin is stimulated by: an increase in serum Calcium [Ca2+] gastrin and pentagastrin. The hormone participates in calcium (Ca2+) metabolism. In many ways...
absorption. H 2 -histamine receptor blockers can counteract the effects of pentagastrin a and histamine a on gastric acid-forming function, so use H 2 blockers...