Granule cells, parallel fibers, and flattened dendritic trees of Purkinje cells
Details
Location
Cerebellum
Shape
small cell with few dendrites
Function
excitatory
Neurotransmitter
glutamate
Presynaptic connections
Mossy fibers and Golgi cells
Postsynaptic connections
Parallel fibers to cerebellar cortex
Anatomical terms of neuroanatomy
[edit on Wikidata]
Cerebellar granule cells form the thick granular layer of the cerebellar cortex and are among the smallest neurons in the brain. (The term granule cell is used for several unrelated types of small neurons in various parts of the brain.) Cerebellar granule cells are also the most numerous neurons in the brain: in humans, estimates of their total number average around 50 billion, which means that they constitute about 3/4 of the brain's neurons.[1]
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Cerebellargranulecells form the thick granular layer of the cerebellar cortex and are among the smallest neurons in the brain. (The term granule cell...
neurons are cerebellargranulecells. Their cell bodies are packed into a thick layer at the bottom of the cerebellar cortex. A granulecell emits only...
cells synapse onto the dendrite of granulecells and unipolar brush cells. They receive excitatory input from mossy fibres, also synapsing on granule...
located in the cerebellar cortex of the brain. With their flask-shaped cell bodies, many branching dendrites, and a single long axon, these cells are essential...
fibers form excitatory synapses with the granulecells and the cells of the deep cerebellar nuclei. The granulecells send their T-shaped axons—known as parallel...
brush cells (UBCs) are a class of excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granulecell domain...
stem cell self-renewal. In both humans and mice, researchers showed Bmi1 to be highly expressed in proliferating immature cerebellargranulecell precursors...
formation of specific kinds of cancerous tumors, including the embryonic cerebellar tumor and medulloblastoma, as well as the progression of prostate cancer...
These nuclei receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber and...
other neurons, they may be smaller, and in some (such as the granule neurons of the cerebellar cortex) very little rough endoplasmic reticulum is present...
the molecular layer in the cerebellum. Cerebellar stellate cells synapse onto the dendritic trees of Purkinje cells and send inhibitory signals. Stellate...
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The cerebellar vermis (from Latin vermis, "worm") is located in the medial, cortico-nuclear zone of the cerebellum, which is in the posterior fossa of...
Cerebellar peduncles connect the cerebellum to the brain stem. There are six cerebellar peduncles in total, three on each side: Superior cerebellar peduncle...
E2F, followed by cell death (Frade and Ovejero-Benito, 2015). In cerebellargranulecells and cortical neurons, E2F1 can trigger neuronal apoptosis through...
Seeburg PH, Lüddens H (February 1995). "Selective antagonist for the cerebellargranulecell-specific gamma-aminobutyric acid type A receptor". Molecular Pharmacology...
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action potentials across cell membranes. Calcium channels can also be used to release calcium ions as second messengers within the cell, affecting downstream...
telodendria, with many synaptic end points. In comparison, the cerebellargranulecell axon is characterized by a single T-shaped branch node from which...
development. Producing granulecells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system. Through...
single glutamate receptor channels in outside-out patches from rat cerebellargranulecells". Journal of Physiology. 432 (1): 143–202. doi:10.1113/jphysiol...
For example, the IC50 for block of L-type calcium channels on a cerebellargranulecell is 0.2 nM, but the IC50 of the block of rat peripheral DRG neuronal...
it is then allowed, thanks to the membrane potential, to flip inside the cell freeing all the elements previously bound. Right after the release of the...
Cxcl3 regulates cell autonomously the migration of the precursors of cerebellargranule neurons toward the internal layers of cerebellum, during the morphogenesis...
pyramidal cells, Purkinje cells, and anterior horn cells Golgi II: neurons whose axonal process projects locally; the best example is the granulecell Anaxonic:...