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The Neuronal cell cycle represents the life cycle of the biological cell, its creation, reproduction and eventual death. The process by which cells divide into two daughter cells is called mitosis. Once these cells are formed they enter G1, the phase in which many of the proteins needed to replicate DNA are made. After G1, the cells enter S phase during which the DNA is replicated. After S, the cell will enter G2 where the proteins required for mitosis to occur are synthesized. Unlike most cell types however, neurons are generally considered incapable of proliferating once they are differentiated, as they are in the adult nervous system. Nevertheless, it remains plausible that neurons may re-enter the cell cycle under certain circumstances. Sympathetic and cortical neurons, for example, try to reactivate the cell cycle when subjected to acute insults such as DNA damage, oxidative stress, and excitotoxicity. This process is referred to as “abortive cell cycle re-entry” because the cells usually die in the G1/S checkpoint before DNA has been replicated.
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The Neuronalcellcycle represents the life cycle of the biological cell, its creation, reproduction and eventual death. The process by which cells divide...
Cellcycle checkpoints are control mechanisms in the eukaryotic cellcycle which ensure its proper progression. Each checkpoint serves as a potential termination...
"Stepwise emergence of the neuronal gene expression program in early animal evolution". Cell. 186 (21): 4676–4693.e29. doi:10.1016/j.cell.2023.08.027. PMC 10580291...
Amniotic stem cells are multipotent and can differentiate in cells of adipogenic, osteogenic, myogenic, endothelial, hepatic and also neuronal lines. Amniotic...
p21 in the frontal association cortex of ALS/MND brains suggests neuronalcellcycle dysregulation and astrocyte senescence in early stages of the disease"...
phase describes a cellular state outside of the replicative cellcycle. Classically[when?], cells were thought to enter G0 primarily due to environmental...
Mitosis (/maɪˈtoʊsɪs/) is a part of the cellcycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis is an equational...
Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the greater its potency. Potency...
biology, cell signaling (cell signalling in British English) is the process by which a cell interacts with itself, other cells, and the environment. Cell signaling...
Glia, also called glial cells (gliocytes) or neuroglia, are non-neuronalcells in the central nervous system (brain and spinal cord) and the peripheral...
frequencies. For example, neuronal activity generated by two populations of interconnected inhibitory and excitatory cells can show spontaneous oscillations...
and cell types, including brain and heart Immune signaling Neuronal mitochondria also contribute to cellular quality control by reporting neuronal status...
closed while the cell was at resting potential are opened in response to an initial change in voltage. As a change in the neuronal charge leads to the...
including cell proliferation control, activity of proto-oncogenic proteins, apoptosis, centrosome duplication, and organization of neuronal dendrites...
Viral neuronal tracing is the use of a virus to trace neural pathways, providing a self-replicating tracer. Viruses have the advantage of self-replication...
during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo...
that will re-enter the cellcycle. This mitosis occurs in the germinal neuroepithelium (or germinal zone), when a radial glial cell divides to produce the...
phenotype, leading to irreversible cellcycle arrest. The generation of cell lines stems from these two reasons. Primary cells can become immortalized either...
of cancer cells in confining micro-environments follows limit cycle oscillations. Some non-linear electrical circuits exhibit limit cycle oscillations...
neural progenitor identity and the emergence of neocortical neuronal diversity". Seminars in Cell and Developmental Biology. 118 (118): 4–13. doi:10.1016/j...
many types of cells and tissues. Other viruses may infect primarily a single tissue. For example, rabies virus affects primarily neuronal tissue. Factors...
extensions that fills the empty space generated by the dead or dying neuronalcells (a process called astrogliosis). The heavy proliferation of astrocytes...
outermost layer of the brain and consists primarily of gray matter, or neuronalcell bodies. Interior areas of the brain consist of myelinated axons and...
Staehling-Hampton, K; Heitzler, P; Dyson, N (2000). "A role for Ebi in neuronalcellcycle control". EMBO J. 19 (20): 5376–86. doi:10.1093/emboj/19.20.5376...
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