Eosinophil cationic protein information

RNASE3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4A2O, 4X08, 1DYT, 4OXB, 2LVZ, 2KB5, 4OXF, 1QMT, 4OWZ, 1H1H, 4A2Y
Identifiers
Aliases	RNASE3, ECP, RNS3, RAF1, ribonuclease A family member 3
External IDs	OMIM: 131398; MGI: 3528616; HomoloGene: 136763; GeneCards: RNASE3; OMA:RNASE3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	20,892,348 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; bone marrow; ; bone marrow cells; ; monocyte; ; blood; ; spleen; ; right lung; ; upper lobe of left lung; ; thymus; ; tibia;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	nuclease activity; endonuclease activity; ribonuclease activity; hydrolase activity; nucleic acid binding; lipopolysaccharide binding;
Cellular component	extracellular region; extracellular space; azurophil granule lumen;
Biological process	RNA catabolic process; innate immune response in mucosa; defense response to bacterium; nucleic acid phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis; antimicrobial humoral response; neutrophil degranulation; antimicrobial humoral immune response mediated by antimicrobial peptide; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	6037
	503847
	ENSG00000169397
	ENSMUSG00000050766
	P12724
	Q5GAN2
	NM_002935
	NM_017389
	NP_002926
	NP_059085
	Wikidata
View/Edit Human	View/Edit Mouse

Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix.^[4] In humans, the eosinophil cationic protein is encoded by the RNASE3 gene.^[5]

ECP is released during degranulation of eosinophils. This protein is related to inflammation and asthma because in these cases, there are increased levels of ECP in the body. There are three glycosylated forms of ECP and consequently ECP has a range of molecular weights from 18-22 kDa.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169397 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Boix E, Carreras E, Nikolovski Z, Cuchillo CM, Nogués MV (June 2001). "Identification and characterization of human eosinophil cationic protein by an epitope-specific antibody". J. Leukoc. Biol. 69 (6): 1027–35. doi:10.1189/jlb.69.6.1027. PMID 11404391. S2CID 11326107.
^ Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (May 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.
^ Lee BioSolutions, Inc. http://www.leebio.com/eosinophil-cationic-protein-human-P359.html Archived 2012-03-06 at the Wayback Machine

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169397 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11404391-4] Boix E, Carreras E, Nikolovski Z, Cuchillo CM, Nogués MV (June 2001). "Identification and characterization of human eosinophil cationic protein by an epitope-specific antibody". J. Leukoc. Biol. 69 (6): 1027–35. doi:10.1189/jlb.69.6.1027. PMID 11404391. S2CID 11326107.

[pmid1577491-5] Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (May 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.

[6] Lee BioSolutions, Inc. http://www.leebio.com/eosinophil-cationic-protein-human-P359.html Archived 2012-03-06 at the Wayback Machine

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