LRDD information

PIDD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OF5
Identifiers
Aliases	PIDD1, LRDD, PIDD, p53-induced death domain protein 1
External IDs	OMIM: 605247; MGI: 1889507; HomoloGene: 11220; GeneCards: PIDD1; OMA:PIDD1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	809,753 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,023,938 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right hemisphere of cerebellum; ; right uterine tube; ; granulocyte; ; mucosa of transverse colon; ; C1 segment; ; right lobe of thyroid gland; ; anterior pituitary; ; left lobe of thyroid gland; ; skin of leg;
	Top expressed in
	thymus; ; yolk sac; ; morula; ; maxillary prominence; ; blastocyst; ; ganglionic eminence; ; proximal tubule; ; abdominal wall; ; ascending aorta; ; spermatocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	death receptor binding; protein binding; volume-sensitive anion channel activity; endopeptidase activity; hydrolase activity;
Cellular component	Golgi apparatus; nucleus; nucleoplasm; cytoplasm; cytosol; ion channel complex;
Biological process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of apoptotic process; positive regulation of apoptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of NF-kappaB transcription factor activity; signal transduction; cellular response to DNA damage stimulus; positive regulation of apoptotic process; regulation of apoptotic process; inorganic anion transport; anion transmembrane transport; protein autoprocessing; regulation of I-kappaB kinase/NF-kappaB signaling; extrinsic apoptotic signaling pathway via death domain receptors; apoptotic signaling pathway; extrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55367
	57913
	ENSG00000177595
	ENSMUSG00000025507
	Q9HB75
	Q9ERV7
	NM_018494; NM_145886; NM_145887
	NM_022654; NM_001360523; NM_001360524
	NP_665893; NP_665894
	NP_073145; NP_001347452; NP_001347453
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177595 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025507 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: LRDD leucine-rich repeats and death domain containing".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177595 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025507 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LRDD leucine-rich repeats and death domain containing".

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