Diablo homolog information

DIABLO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FEW, 1G3F, 1G73, 1OXQ, 1TW6, 1XB0, 1XB1, 3D9U, 3UIH, 3UIJ, 4TX5
Identifiers
Aliases	DIABLO, DFNA64, SMAC, Diablo, Diablo homolog, diablo IAP-binding mitochondrial protein
External IDs	OMIM: 605219 MGI: 1913843 HomoloGene: 10532 GeneCards: DIABLO
Gene location (Human)
Chr.	Chromosome 12 (human)
End	122,227,456 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	123,662,239 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; anterior pituitary; ; ganglionic eminence; ; hypothalamus; ; substantia nigra; ; corpus callosum; ; placenta; ; amygdala; ; putamen; ; kidney;
	Top expressed in
	spermatocyte; ; spermatid; ; morula; ; lip; ; yolk sac; ; superior frontal gyrus; ; neural tube; ; thymus; ; proximal tubule; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; mitochondrial intermembrane space; mitochondrion; cytoplasmic side of plasma membrane; CD40 receptor complex;
Biological process	intrinsic apoptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; positive regulation of apoptotic process; intrinsic apoptotic signaling pathway in response to oxidative stress; neuron apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	56616
	66593
	ENSG00000184047
	ENSMUSG00000029433
	Q9NR28
	Q9JIQ3
NM_138930; NM_001278302; NM_001278303; NM_001278304; NM_001278342;
	NM_019887; NM_138929; NM_001371333
	NM_023232
NP_001265231; NP_001265232; NP_001265233; NP_001265271; NP_063940;
	NP_620308; NP_001358262; NP_001265231.1
	NP_075721
	Wikidata
View/Edit Human	View/Edit Mouse

Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the DIABLO (direct IAP binding protein with low pI) gene on chromosome 12.^[5]^[6]^[7] DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis.^[7]^[8] Due to its proapoptotic function, SMAC is implicated in a broad spectrum of tumors, and small molecule SMAC mimetics have been developed to enhance current cancer treatments.^[7]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184047 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029433 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McNeish IA, Bell S, McKay T, Tenev T, Marani M, Lemoine NR (June 2003). "Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway". Experimental Cell Research. 286 (2): 186–98. doi:10.1016/S0014-4827(03)00073-9. PMID 12749848.
^ Yu J, Wang P, Ming L, Wood MA, Zhang L (June 2007). "SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events". Oncogene. 26 (29): 4189–98. doi:10.1038/sj.onc.1210196. PMID 17237824. S2CID 25230886.
^ ^a ^b ^c "Entrez Gene: DIABLO diablo homolog (Drosophila)".
^ Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM (April 2002). "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)". The Journal of Biological Chemistry. 277 (14): 12275–9. doi:10.1074/jbc.M112045200. PMID 11801603.
^ Bai L, Smith DC, Wang S (October 2014). "Small-molecule SMAC mimetics as new cancer therapeutics". Pharmacology & Therapeutics. 144 (1): 82–95. doi:10.1016/j.pharmthera.2014.05.007. PMC 4247261. PMID 24841289.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184047 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029433 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12749848-5] McNeish IA, Bell S, McKay T, Tenev T, Marani M, Lemoine NR (June 2003). "Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway". Experimental Cell Research. 286 (2): 186–98. doi:10.1016/S0014-4827(03)00073-9. PMID 12749848.

[pmid17237824-6] Yu J, Wang P, Ming L, Wood MA, Zhang L (June 2007). "SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events". Oncogene. 26 (29): 4189–98. doi:10.1038/sj.onc.1210196. PMID 17237824. S2CID 25230886.

[entrez-7] "Entrez Gene: DIABLO diablo homolog (Drosophila)".

[pmid11801603-8] Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM (April 2002). "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)". The Journal of Biological Chemistry. 277 (14): 12275–9. doi:10.1074/jbc.M112045200. PMID 11801603.

[pmid24841289-9] Bai L, Smith DC, Wang S (October 2014). "Small-molecule SMAC mimetics as new cancer therapeutics". Pharmacology & Therapeutics. 144 (1): 82–95. doi:10.1016/j.pharmthera.2014.05.007. PMC 4247261. PMID 24841289.

Diablo homolog information

and 12 Related for: Diablo homolog information

Diablo homolog

Diablo

SMAC

Programmed cell death

Survivin

Lymphotoxin beta receptor

XIAP

List of unusual biological names

CLPB

Inhibitor of apoptosis

Lead

P53 upregulated modulator of apoptosis