ERN1 information

ERN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HZ6, 3P23, 4U6R, 4Z7G, 4Z7H, 4YZC, 4YZ9, 4YZD, 5HGI
Identifiers
Aliases	ERN1, IRE1, IRE1P, IRE1a, hIRE1p, endoplasmic reticulum to nucleus signaling 1
External IDs	OMIM: 604033; MGI: 1930134; HomoloGene: 55580; GeneCards: ERN1; OMA:ERN1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	64,130,819 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,378,678 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; decidua; ; amniotic fluid; ; secondary oocyte; ; right adrenal cortex; ; seminal vesicula; ; left adrenal cortex; ; body of pancreas; ; caput epididymis; ; germinal epithelium;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; gastrula; ; decidua; ; seminal vesicula; ; lacrimal gland; ; submandibular gland; ; adrenal gland; ; zygote; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; nucleotide binding; ADP binding; ribonuclease activity; identical protein binding; protein kinase activity; transferase activity; magnesium ion binding; hydrolase activity; Hsp70 protein binding; kinase activity; Hsp90 protein binding; catalytic activity; endonuclease activity; ATP binding; enzyme binding; protein binding; endoribonuclease activity; protein serine/threonine kinase activity; platelet-derived growth factor receptor binding; protein homodimerization activity; unfolded protein binding;
Cellular component	AIP1-IRE1 complex; cytoplasm; integral component of membrane; mitochondrion; IRE1-TRAF2-ASK1 complex; IRE1-RACK1-PP2A complex; nuclear inner membrane; Ire1 complex; membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	positive regulation of endoplasmic reticulum unfolded protein response; mRNA catabolic process; transcription, DNA-templated; insulin metabolic process; peptidyl-serine autophosphorylation; cellular response to vascular endothelial growth factor stimulus; protein autophosphorylation; metabolism; apoptotic process; mRNA splicing, via endonucleolytic cleavage and ligation; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; cellular response to glucose stimulus; peptidyl-serine trans-autophosphorylation; protein phosphorylation; response to unfolded protein; mRNA processing; response to endoplasmic reticulum stress; regulation of transcription, DNA-templated; endothelial cell proliferation; regulation of macroautophagy; phosphorylation; endoplasmic reticulum unfolded protein response; positive regulation of vascular associated smooth muscle cell proliferation; RNA phosphodiester bond hydrolysis, endonucleolytic; positive regulation of RNA splicing; IRE1-mediated unfolded protein response; mRNA cleavage involved in mRNA processing; mRNA cleavage; Unfolded Protein Response;
	Sources:Amigo / QuickGO
Orthologs
	2081
	78943
	ENSG00000178607
	ENSMUSG00000020715
	O75460
	Q9EQY0
	NM_152461; NM_001433
	NM_023913
	NP_001424
	NP_076402
	Wikidata
View/Edit Human	View/Edit Mouse

The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178607 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020715 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tirasophon W, Welihinda AA, Kaufman RJ (June 1998). "A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells". Genes & Development. 12 (12): 1812–1824. doi:10.1101/gad.12.12.1812. PMC 316900. PMID 9637683.
^ "Entrez Gene: ERN1 endoplasmic reticulum to nucleus signalling 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178607 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020715 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9637683-5] Tirasophon W, Welihinda AA, Kaufman RJ (June 1998). "A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells". Genes & Development. 12 (12): 1812–1824. doi:10.1101/gad.12.12.1812. PMC 316900. PMID 9637683.

[entrez-6] "Entrez Gene: ERN1 endoplasmic reticulum to nucleus signalling 1".

ERN1 information

and 4 Related for: ERN1 information

ERN1

BZIP intron animal

Protein kinase domain

YIF1A