Carfilzomib, sold under the brand name Kyprolis, is an anti-cancer medication acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin.[4] It was developed by Onyx Pharmaceuticals.
The US Food and Drug Administration (FDA) approved it in July 2012.[5][6]
^"Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
^"Health Canada New Drug Authorizations: 2016 Highlights". Health Canada. 14 March 2017. Retrieved 7 April 2024.
^ ab"Kyprolis- carfilzomib injection, powder, lyophilized, for solution". DailyMed. 26 August 2020. Retrieved 13 November 2020.
^"NCI Drug Dictionary". National Cancer Institute. Retrieved 13 November 2020.
^"FDA Approves Kyprolis for Some Patients with Multiple Myeloma". FDA. 2012-07-20. Archived from the original on 2013-01-28. Retrieved 2013-07-23.
^"Drug Approval Package: Kyprolis (carfilzomib) for Injection NDA #202714". U.S. Food and Drug Administration (FDA). 20 August 2012. Retrieved 10 April 2023.
Carfilzomib, sold under the brand name Kyprolis, is an anti-cancer medication acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide...
lenalidomide or pomalidomide), and a proteasome inhibitor (e.g., or bortezomib, carfilzomib or ixazomib), in combination with a steroid (e.g., dexamethasone). While...
ixabepilone which is an analogue of the natural product epothilone B and carfilzomib which is derived from epoxomicin and eravacycline derived from tetracycline...
product candidate, carfilzomib (PR-171), is a tetrapeptide epoxyketone for treating multiple myeloma, a blood cancer. The drug carfilzomib works by preventing...
Parkinson's-like symptoms in rats. Derivatives of epoxomicin include carfilzomib. Epoxomicin, Santa Cruz Biotechnology Meng, L; Mohan, R; Kwok, BH; Elofsson...
treatment of last resort) and breast (in comparison to capecitabine). Carfilzomib (marketed under the trade name Kyprolis) was approved by the FDA on June...
and a proteasome inhibitor. It is also indicated in combination with carfilzomib and dexamethasone, for the treatment of adults with relapsed or refractory...
pomalidomide) plus a proteasome inhibitor (bortezomib, ixazomib, or carfilzomib. As the end stage of multiple myeloma that has failed or broken through...
October, Amgen acquired Onyx Pharmaceuticals, developer of Kyprolis (carfilzomib). 2014: In November the company announced it was halting all trials of...