Epoxomicin information

Epoxomicin^[1]
Names
	IUPAC name (2S,3S)-N-((2S,3R)-3-hydroxy-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxobutan-2-yl)-3-methyl-2-((2S,3S)-3-methyl-2-(N-methylacetamido)pentanamido)pentanamide
	Other names BU 4061T
Identifiers
CAS Number	134381-21-8 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL207990 ;
PubChem CID	16760412;
UNII	Y0900I3U8U ;
CompTox Dashboard (EPA)	DTXSID5044073 ;
	SMILES O=C([C@@]1(C)CO1)[C@H](CC(C)C)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)N(C)C(C)=O)=O)=O)[C@H](O)C)=O;
Properties
Chemical formula	C28H50N4O7
Molar mass	554.729 g·mol−1
Appearance	White solid
Solubility in DMSO	10 mg/mL
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Epoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity.^[2] It was originally discovered in 1992.^[3] Injected, it can induce Parkinson's-like symptoms in rats.

Derivatives of epoxomicin include carfilzomib.

^ Epoxomicin, Santa Cruz Biotechnology
^ Meng, L; Mohan, R; Kwok, BH; Elofsson, M; Sin, N; Crews, CM (1999). "Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity". PNAS. 96 (18): 10403–10408. doi:10.1073/pnas.96.18.10403. PMC 17900. PMID 10468620.
^ Epoxomicin, Peptide Institute, Inc.

[1] Epoxomicin, Santa Cruz Biotechnology

[2] Meng, L; Mohan, R; Kwok, BH; Elofsson, M; Sin, N; Crews, CM (1999). "Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity". PNAS. 96 (18): 10403–10408. doi:10.1073/pnas.96.18.10403. PMC 17900. PMID 10468620.

[3] Epoxomicin, Peptide Institute, Inc.

Epoxomicin information

and 5 Related for: Epoxomicin information

Epoxomicin

Carfilzomib

Diverted total synthesis

Proteasome inhibitor

ANKRD1