Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer.[10] This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia.[10] It is often used together with other chemotherapy agents.[10] Doxorubicin is given by injection into a vein.[10]
Common side effects include hair loss, bone marrow suppression, vomiting, rash, and inflammation of the mouth.[10] Other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia.[10] People often experience red discoloration of the urine for a few days.[10] Doxorubicin is in the anthracycline and antitumor antibiotic family of medications.[10] It works in part by interfering with the function of DNA.[11]
Doxorubicin was approved for medical use in the United States in 1974.[10] It is on the World Health Organization's List of Essential Medicines.[12][13] Versions that are pegylated and in liposomes are also available; however, they are more expensive.[13] Doxorubicin was originally made from the bacterium Streptomyces peucetius.[14]
^ ab"Caelyx pegylated liposomal EPAR". European Medicines Agency (EPAR). 17 September 2018. Archived from the original on 21 June 2022. Retrieved 20 June 2022.
^ abCite error: The named reference Myocet liposomal EPAR was invoked but never defined (see the help page).
^ abCite error: The named reference Zolsketil pegylated liposomal EPAR was invoked but never defined (see the help page).
^ ab"Celdoxome pegylated liposomal EPAR". European Medicines Agency (EMA). 20 June 2022. Retrieved 31 January 2023. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^"Caelyx product information". Health Canada. 25 April 2012. Archived from the original on 21 June 2022. Retrieved 20 June 2022.
^"Myocet product information". Health Canada. 25 April 2012. Retrieved 20 June 2022.
^"Taro-doxorubicin liposomal product information". Health Canada. 25 April 2012. Archived from the original on 14 May 2021. Retrieved 20 June 2022.
^ abc"(doxorubicin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 16 April 2014. Retrieved 15 April 2014.
^Brayfield A, ed. (19 December 2013). "Doxorubicin". Martindale: The Complete Drug Reference. Pharmaceutical Press. Archived from the original on 28 August 2021. Retrieved 15 April 2014.
^ abcdefghi"Doxorubicin Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 11 October 2016. Retrieved 12 January 2017.
^Tacar O, Sriamornsak P, Dass CR (February 2013). "Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems". The Journal of Pharmacy and Pharmacology. 65 (2): 157–170. doi:10.1111/j.2042-7158.2012.01567.x. PMID 23278683. S2CID 34737360.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ abBritish national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 583. ISBN 9780857111562.
^Ravina E (2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. p. 291. ISBN 9783527326693. Archived from the original on 18 September 2017.
Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder...
Zoptarelin doxorubicin (developmental code names AEZS-108, AN-152) consists of doxorubicin linked to a small peptide agonist to the luteinizing hormone-releasing...
of Actinomycetota. Clinically the most important anthracyclines are doxorubicin, daunorubicin, epirubicin and idarubicin. The anthracyclines are among...
Doxorubicin (DXR) is a 14-hydroxylated version of daunorubicin, the immediate precursor of DXR in its biosynthetic pathway. Daunorubicin is more abundantly...
undergo growth and become primary spermatocytes. Anticancer drugs such as doxorubicin and vincristine can adversely affect male fertility by damaging the DNA...
prominent with the use of anthracycline drugs (doxorubicin, epirubicin, idarubicin, and liposomal doxorubicin). The cause of this is most likely due to the...
Epimerization is the interconversion of one epimer to the other epimer. Doxorubicin and epirubicin are two epimers that are used as drugs. The stereoisomers...
splenectomy followed by Doxorubicin did better then dogs treated with splenectomy and mushroom agent. Combination of Doxorubicin with the Turkey Tail mushroom...
radicals that cause cell and DNA damage. Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it...
anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II...
adverse reactions to many drugs, including acepromazine, butorphanol, doxorubicin, erythromycin, ivermectin, loperamide, milbemycin, moxidectin, rifampin...
arising from specific genomic translocations, mainly involving topo IIβ. Doxorubicin (Fig. 7) and the related derivatives daunorubicin, epirubicin, and idarubicin...
chemotherapy regimens used include: Doxorubicin and cyclophosphamide Doxorubicin and cyclophosphamide followed by docetaxel Doxorubicin and cyclophosphamide followed...
for semi-synthetic manufacturing of doxorubicin, epirubicin and idarubicin.[citation needed] Similar to doxorubicin, daunorubicin interacts with DNA by...
name has one widely agreed pronunciation in each language. For example, doxorubicin is consistently /ˌdɒksoʊˈruːbɪsɪn/ in English. Trade names almost always...
drug and tumor cells. In particular, anthracycline antitumor antibiotic doxorubicin, the native state of which is diamagnetic, acquires the magnetic properties...
chemotherapeutic drugs such as anthracyclines, such as daunorubicin or doxorubicin or other chemotherapeutic agents. However, in July 2011 the European...
a tumor-targeted doxorubicin conjugate in development by CytRx. Specifically, it is the (6-maleimidocaproyl) hydrazone of doxorubicin. Essentially, this...
B-cell lymphoma. Polivy in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) is indicated for the treatment of adults with...
cutaneous adherence, it can also be caused by the chemotherapy medication doxorubicin and ketoconazole. List of syndromes Darsha, Adrija K; Cohen, Philip R...
been previously treated with doxorubicin. In a randomised controlled trial with 133 STS patients, olaratumab plus doxorubicin improved the median of progression-free...
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