For the isomer of tretinoin used primarily to treat more severe acne, see Isotretinoin. For all-trans-retinoic acid as the metabolite of vitamin A, see Retinoic acid.
Tretinoin, also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia.[8][9][10] For acne, it is applied to the skin as a cream, gel or ointment.[10] For leukemia, it is taken by mouth for up to three months.[8] Topical tretinoin is also the most extensively investigated retinoid therapy for photoaging.[11]
Common side effects when used as a cream are limited to the skin and include skin redness, peeling, and sun sensitivity.[10] When used by mouth, side effects include shortness of breath, headache, numbness, depression, skin dryness, itchiness, hair loss, vomiting, muscle pains, and vision changes.[8] Other severe side effects include high white blood cell counts and blood clots.[8] Use during pregnancy is contraindicated due to the risk of birth defects.[8][1] It is in the retinoid family of medications.[9]
Tretinoin was patented in 1957, and approved for medical use in 1962.[12] It is on the World Health Organization's List of Essential Medicines.[13] Tretinoin is available as a generic medication.[14] In 2021, it was the 206th most commonly prescribed medication in the United States, with more than 2million prescriptions.[15][16]
^ ab"Tretinoin (Vesanoid) Use During Pregnancy". Drugs.com. 25 July 2019. Retrieved 16 January 2020.
^"Tretinoin topical Use During Pregnancy". Drugs.com. 1 July 2019. Retrieved 16 January 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 15 August 2023.
^Cite error: The named reference OralLabel was invoked but never defined (see the help page).
^Cite error: The named reference TopicalLabel was invoked but never defined (see the help page).
^"List of nationally authorised medicinal products:Active substance(s): tretinoin (oral formulations)" (PDF). ema.europa.eu. European Medicines Agency. 1 December 2022. Archived (PDF) from the original on 30 January 2023.
^ abcde"Tretinoin". The American Society of Health-System Pharmacists. Archived from the original on 30 November 2016. Retrieved 8 December 2016.
^ abTivnan A (2016). Resistance to Targeted Therapies Against Adult Brain Cancers. Springer. p. 123. ISBN 978-3-319-46505-0. Archived from the original on 5 November 2017.
^ abcBritish national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 627, 821–822. ISBN 978-0-85711-156-2.
^"Retinoids, topical". American Osteopathic College of Dermatology.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 476. ISBN 978-3-527-60749-5. Archived from the original on 5 November 2017.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"Tretinoin topical". The American Society of Health-System Pharmacists. Archived from the original on 16 May 2016. Retrieved 8 December 2016.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Tretinoin - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Tretinoin, also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia. For acne, it...
over other retinoids. The adapalene molecule is more stable compared to tretinoin and tazarotene, which leads to less concern for photodegradation. It is...
characteristic changes to skin induced by chronic UVA and UVB exposure.: 29 Tretinoin is the best studied retinoid in the treatment of photoaging. The deterioration...
repairing sun-damaged skin, and more recently it has been compounded with tretinoin as a topical treatment for acne. Bisabolol is known to have anti-irritant...
mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% mequinol and 0.01% tretinoin by mass. Dermatologists...
specifically associated with all-trans retinoic acid (ATRA) (also known as tretinoin) treatment. Subsequently, so-called RAS was recognized in APML patients...
retinol or retinal. As for the risks of too much RA, the prescription drugs tretinoin (all-trans-retinoic acid) and isotretinoin (13-cis-retinoic acid), used...
suggests that tretinoin decreases cohesiveness of follicular epithelial cells, although the exact mode of action is unknown. Additionally, tretinoin stimulates...
tried including laser treatments, glycolic acid, and microdermabrasion. Tretinoin (0.1% w/w), which is a retinoid, has found to be effective on early stretch...
and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug. The most common adverse effects are dry lips (cheilitis)...
by its responsiveness to all-trans retinoic acid (ATRA; also known as tretinoin) therapy. Acute promyelocytic leukemia was first characterized in 1957...
treat acne vulgaris and psoriasis. Like other topical retinoids, such as tretinoin and adapalene, tazarotene can be combined with benzoyl peroxide or an...
inhibits tyrosinase, an enzyme involved in the production of melanin. Tretinoin, a retinoid, increases skin cell (keratinocyte) turnover. This treatment...
made cancer cells make hemoglobin; Lorraine Baltzer, a research nurse; tretinoin was found to work in 1988, and first prescribed in September 1990; Bruce...
strength, it’s considered to be as effective as benzoyl peroxide 5%, tretinoin 0.05%, erythromycin 2%, and oral tetracycline at 500 mg-1000 mg. In a...
retinoid that can be combined with benzoyl peroxide unlike tezarotene and tretinoin. Combination products such as benzoyl peroxide/clindamycin and benzoyl...
used topically to help treat skin lesions from Kaposi's sarcoma, and tretinoin (all-trans- retinoic acid) is used to treat acute promyelocytic leukemia...
Minnesota Renova (brand), a Portuguese paper products company Trade name of tretinoin, a treatment for acne and other skin conditions Renova Group, a Russian...
antibiotics. Tretinoin is a potent treatment that helps even out any scarring after a few months. It is added as a nightly application of tretinoin cream 0...
allowed in cosmetics in Europe, a number of others such as hydroquinone and tretinoin are not. While some countries do not allow mercury compounds in cosmetics...
Isotretinoin Methoxyflurane Pseudoephedrine in large doses Salmeterol Tramadol Tretinoin Trimethoprim All benzodiazepines except flunitrazepam and alprazolam All:...
acid, salicylic acid, vitamin D, fish oil, or topical retinoids such as tretinoin. Improvement of the skin often takes months, and the bumps are likely...
5% benzoyl peroxide gel in the morning and applied a micronized 0.05% tretinoin gel in the evening the overwhelming majority of patients experienced no...
option to treat with carbon dioxide laser therapy, followed by topical tretinoin therapy has been described. Surgery may be necessary to remove large nodules...
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