Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Carboxyglutamic acid (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues. This modification is found, for example, in clotting factors and other proteins of the coagulation cascade. This modification introduces an affinity for calcium ions. In the blood coagulation cascade, vitamin K is required to introduce γ-carboxylation of clotting factors II, VII, IX, X and protein Z.[1]
^J Stenflo, and J W Suttie (1977). "Vitamin K–dependent formation of γ-carboxyglutamic acid". Annual Review of Biochemistry. 46: 157–172. doi:10.1146/annurev.bi.46.070177.001105. PMID 332061.
and 19 Related for: Carboxyglutamic acid information
Carboxyglutamicacid (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post-translational carboxylation...
Osteocalcin, also known as bone gamma-carboxyglutamicacid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found...
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate...
K-dependent reaction that converts 10-12 glutamic acids in the N terminus of the molecule to gamma-carboxyglutamicacid (Gla). In the presence of calcium, the Gla...
(July 1980). "Mechanism Of Action Of Vitamin K: Synthesis Of Y-CarboxyglutamicAcid". Critical Reviews in Biochemistry. 8 (2): 191–223. doi:10.3109/10409238009105469...
Carboxylation is a chemical reaction in which a carboxylic acid is produced by treating a substrate with carbon dioxide. The opposite reaction is decarboxylation...
anticoagulants like EDTA and citrate salts work by binding calcium (see carboxyglutamicacid), but they may also bind other ions. Even if such ions are not the...
(molar mass: 191.14 g/mol) may refer to: Carboxyglutamicacid Isosorbide mononitrate Nitrilotriacetic acid This set index page lists chemical structure...
Esmon CT (May 1983). "Proteolytic formation and properties of gamma-carboxyglutamicacid-domainless protein C". The Journal of Biological Chemistry. 258 (9):...
heavy chain (306 residues). The light chain contains an N-terminal γ-carboxyglutamicacid domain (Gla domain) and two epidermal growth factor-like domains...
"Timed appearance of a calcium-binding protein containing gamma-carboxyglutamicacid in developing chick bone". Developmental Biology. 65 (2): 426–34...
gamma-carboxyglutamicacid, NH2 = C-terminal amidation and the remainder of the letters refer to the standard one letter abbreviations for amino acids. The...
43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts. Gas6 is a gamma-carboxyglutamicacid (Gla) domain-containing...
especially in the bone by carboxylating an amino acid glutamic acid (Glu) to gamma carboxyglutamicacid (Gla). There are controversial results in many studies...
RD, Hill RL (May 2009). "The Finding That Prothrombin Contains γ-CarboxyglutamicAcid: the Work of Johan Stenflo". Journal of Biological Chemistry. 284...
Pedersen LG, Furie BC, Furie B (December 1997). "Role of gamma-carboxyglutamicacid in the calcium-induced structural transition of conantokin G, a conotoxin...
Furie, Barbara C. (1999). "Vitamin K-Dependent Biosynthesis of γ-CarboxyglutamicAcid". Blood. 93 (6): 1798–1808. doi:10.1182/blood.v93.6.1798.406k22_1798_1808...
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