Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[8] It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs). It is a reasonable initial treatment for high blood pressure.[8] It is taken by mouth.[8]
Common side effects include feeling tired, dizziness, high blood potassium, diarrhea, and joint pain.[8] Other serious side effects may include kidney problems, low blood pressure, and angioedema.[8] Use in pregnancy may harm the baby and use when breastfeeding is not recommended.[9] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.[8]
Valsartan was patented in 1990, and came into medical use in 1996.[10] It is available as a generic medication.[11] In 2021, it was the 120th most commonly prescribed medication in the United States, with more than 5million prescriptions.[12][13] Versions are available as the combinations valsartan/hydrochlorothiazide,[14] valsartan/amlodipine,[15] valsartan/amlodipine/hydrochlorothiazide,[16] valsartan/nebivolol,[17] and valsartan/sacubitril.[8][18]
^"Valsartan Use During Pregnancy". Drugs.com. 28 March 2019. Retrieved 12 February 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^"Diovan valsartan 40mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.
^"Diovan valsartan 80mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.
^"Diovan valsartan 160mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.
^"Valsartan 160 mg capsules - Summary of Product Characteristics (SmPC)". (emc). 19 February 2019. Archived from the original on 13 February 2020. Retrieved 12 February 2020.
^Cite error: The named reference Diovan FDA label was invoked but never defined (see the help page).
^ abcdefg"Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^"Valsartan Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
^Fischer J, Ganellin CR, eds. (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 470. ISBN 9783527607495.
^British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Valsartan - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
^"Valsartan and hydrochlorothiazide Advanced Patient Information". Drugs.com. 29 January 2024. Retrieved 7 February 2024.
^"Amlodipine and valsartan Advanced Patient Information". Drugs.com. 27 June 2023. Retrieved 7 February 2024.
^"Amlodipine, valsartan, and hydrochlorothiazide Advanced Patient Information". Drugs.com. 2 December 2023. Retrieved 7 February 2024.
^"Nebivolol and valsartan Advanced Patient Information". Drugs.com. 14 October 2023. Retrieved 7 February 2024.
^"Sacubitril and Valsartan Monograph for Professionals". Drugs.com. 7 November 2019. Retrieved 12 February 2020.
Consumer Level Recall of 80 Lots of Amlodipine Valsartan Tablets USP, Valsartan HCTZ Tablets, USP and Valsartan Tablets USP, Due to the Detection of NDEA...
Limited Issues Voluntary Nationwide Recall of Valsartan/Amlodipine/HCTZ, Valsartan/Amlodipine and Valsartan Tablets". Food and Drug Administration. 2018...
an antihypertensive drug used in combination with valsartan. The combination drug sacubitril/valsartan, known during trials as LCZ696 and marketed under...
versions of the angiotensin II receptor blocker medicines (including valsartan, losartan, irbesartan and other "-sartan" drugs) contain nitrosamine impurities...
failure patients, angiotensin receptor blockers such as candesartan and valsartan may be a suitable option for those who do not tolerate angiotensin-converting...
Issues Voluntary Nationwide Recall of All Amlodipine/Valsartan Combination Tablets and Amlodipine/Valsartan/Hydrochlorothiazide Combination Tablets That Are...
Farsang C, Maggioni AP, Glazer RD, Aknay N, et al. (2004). "Effect of valsartan added to background ACE inhibitor therapy in patients with heart failure:...
azilsartan candesartan eprosartan irbesartan losartan olmesartan telmisartan valsartan fimasartan In 2004, an article in the BMJ examined the evidence for and...
Expands Its Voluntary Nationwide Recall of Valsartan Tablets, USP, Amlodipine and Valsartan Tablets, USP, and Valsartan and Hydrochlorothiazide Tablets, USP...
angiotensin II receptor antagonist. Amlodipine/valsartan or amlodipine/valsartan/hydrochlorothiazide, where valsartan is an angiotensin II receptor antagonist...
C09DB08 Valsartan and lercanidipine C09DB09 Fimasartan and amlodipine C09DX01 Valsartan, amlodipine and hydrochlorothiazide C09DX02 Valsartan and aliskiren...
than 60 ml/min). Novartis decided to stop marketing Valturna (aliskiren/valsartan). Aliskiren was co-developed by the Swiss pharmaceutical companies Novartis...
continuing development of several other ARBs. Valsartan, candesartan and irbesartan were all developed in 1990. Valsartan, first marketed by Novartis, is a nonheterocyclic...
failure. The angiotensin receptor-neprilysin inhibitors (ARNI) sacubitril/valsartan is recommended as first choice of RAS inhibitors in American guidelines...
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