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Calponin 2 information


CNN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNN2, calponin 2
External IDsOMIM: 602373; MGI: 105093; HomoloGene: 3215; GeneCards: CNN2; OMA:CNN2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_201277
NM_001303499
NM_001303501
NM_004368

NM_007725

RefSeq (protein)

NP_001290428
NP_001290430
NP_004359
NP_958434

NP_031751

Location (UCSC)Chr 19: 1.03 – 1.04 MbChr 10: 79.82 – 79.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calponin 2 is a protein that in humans is encoded by the CNN2 gene.

The CNN2 gene is located at 19p13.3 in the human chromosomal genome,[5] encoding the protein calponin 2. Calponin 2 is one of the three isoforms of calponin and an actin filament-associated regulatory protein with wide tissue distributions. Human calponin 2 is a 33.7-kDa protein consisting of 309 amino acids with an isoelectric point (pI) of 7.23. Accordingly, it is also known as neutral calponin.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000064666 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004665 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Masuda H, Tanaka K, Takagi M, Ohgami K, Sakamaki T, Shibata N, Takahashi K (1996). "Molecular cloning and characterization of human non-smooth muscle calponin". Journal of Biochemistry. 120 (2): 415–24. doi:10.1093/oxfordjournals.jbchem.a021428. PMID 8889829.

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Calponin 2

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human chromosomal genome, encoding the protein calponin 2. Calponin 2 is one of the three isoforms of calponin and an actin filament-associated regulatory...

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Calponin

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Calponin is a calcium binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein...

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Calponin 1

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encoding three isoforms of calponin: calponin 1, calponin 2, calponin 3, respectively. Protein sequence alignment shows that calponin 1 is highly conserved...

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Calponin homology domain

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Calponin homology domain (or CH domain) is a family of actin binding domains found in both cytoskeletal proteins and signal transduction proteins. The...

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Fimbrin

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protein important in the formation of filopodia. Fimbrin belongs to the calponin homology (CH) domain superfamily of actin cross-linking proteins. Like...

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CFAP47

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also related to Calponin, a calcium binding protein. In the 324 to 403 base pair region, there is a Calponin homology domain. Calponin homology domains...

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Caldesmon

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encoded by the CALD1 gene. Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle...

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Plastin

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each of their polypeptide in which each ABD contains two of 125-residue calponin-homology (CH) components. This structure allows for plastins to cross-link...

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Smooth muscle

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calmodulin (which takes on the regulatory role in smooth muscle), caldesmon and calponin are significant proteins expressed within smooth muscle. Tropomyosin is...

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Chromatophore

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iridophores have been found to contain the smooth muscle regulatory proteins [calponin] and caldesmon. Leaving the neural crest in waves, chromatophores take...

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Invasive cribriform carcinoma of the breast

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myoepithelial marker proteins such as tumor protein 63, smooth muscle actin, calponin, or CD10. The diagnosis of ICCB tumors is based on the histopathology and...

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Perivascular epithelioid cell tumour

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(HMB-45, Melan A (Mart 1), Mitf) and myogenic markers (actin, myosin, calponin). PECs bear significant histologic and immunohistochemical similarity to:...

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Adhesome

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target proteins to the plasma membrane; Calponin homology (CH) domain, which is an F-actin binding motif; Src homology 2 (SH2) domain, which mediate interaction...

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CALM2

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Biology. 76 (2–3): 313–323. doi:10.1139/bcb-76-2-3-313. PMID 9923700. Gusev NB (October 2001). "Some properties of caldesmon and calponin and the participation...

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MICAL1

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NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene. MICAL1 has been shown to interact...

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OP9 cell

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factor (M-CSF). Certain markers, including CD140a+ , CD140b+ , α-SMA+ and Calponin+, indicate a perivascular origin of this cell line. OP9 cells have been...

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Spindle checkpoint

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attachment to the kinetochore. Endogenous Mps1 is shown to associate with the calponin-homology (CH) domain of Ndc80, which is located in the outer kinetochore...

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CAMSAP2

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polymerization. In addition to a CKK domain, CAMSAP2 contains an N-terminal calponin homology domain involved with actin binding. CAMSAP2 proteins are observed...

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Ischemic fasciitis

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vimentin protein, and collagen type IV protein, but not keratin, S100, calponin, or CD34 proteins. The finding that a tumor's cells have some of these...

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Ductal carcinoma in situ

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invasive cancer measuring up to 1.0 mm in size. Immunohistochemistry for calponin in ductal carcinoma in situ, highlighting myoepithelial cells around all...

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Stress granule

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condensates in the cytosol composed of proteins and RNAs that assemble into 0.1–2 μm membraneless organelles when the cell is under stress. The mRNA molecules...

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ARHGEF7

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SNX27 proteins. Some splice variants of βPIX contain an amino-terminal Calponin Homology (CH) domain whose functions remain relatively poorly defined,...

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Craniofacial cleft

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R.A., et al. (2015). Mutations in SPECC1L, encoding sperm antigen with calponin homology and coiled-coil domains 1-like, are found in some cases of autosomal...

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Necrotizing sialometaplasia

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low immunoreactivity for MIB1 (Ki-67), and the presence of 4A4/p63- and calponin-positive myoepithelial cells. No surgery is required. Healing is prolonged...

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Actinin

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all members of the superfamily have. This is made up of two consecutive calponin homology (CH) where spectrin repeats comes right after it. This allows...

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Muscle contraction

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filament protein tropomyosin and other notable proteins – caldesmon and calponin. Thus, smooth muscle contractions are initiated by the Ca2+ -activated...

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Selenium responsive proteins

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name Responsive in Selenium compound technique used source Q08091 CNN1 Calponin-1 TRAMP (prostate cancer mouse model) MSeC iTRAQ LC-MS/MS Zhang 2010 NP_035656...

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