Caldesmon information

CALD1
Identifiers
Aliases	CALD1, CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22, caldesmon 1, h-CD
External IDs	OMIM: 114213; HomoloGene: 137424; GeneCards: CALD1; OMA:CALD1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	134,970,729 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; tail of epididymis; ; seminal vesicula; ; tendon of biceps brachii; ; urethra; ; superficial temporal artery; ; visceral pleura; ; parietal pleura; ; stromal cell of endometrium; ; right coronary artery;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	myosin binding; actin binding; tropomyosin binding; protein binding; calmodulin binding; cadherin binding;
Cellular component	cytoplasm; cytosol; plasma membrane; myofibril; cytoskeleton; actin cytoskeleton; intracellular membrane-bounded organelle; membrane; actin cap;
Biological process	muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	800
	n/a
	ENSG00000122786
	n/a
	Q05682
	n/a
	NM_004342; NM_033138; NM_033139; NM_033140; NM_033157
	n/a
	NP_004333; NP_149129; NP_149130; NP_149131; NP_149347
	n/a
	Wikidata
View/Edit Human

Caldesmon is a protein that in humans is encoded by the CALD1 gene.^[3]^[4]

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to ${\text{Ca}}^{2+}$ -calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for ${\text{Ca}}^{2+}$ -dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.^[4]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122786 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Novy RE, Lin JL, Lin JJ (Oct 1991). "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem. 266 (25): 16917–24. doi:10.1016/S0021-9258(18)55390-4. PMID 1885618.
^ ^a ^b "Entrez Gene: CALD1 caldesmon 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122786 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1885618-3] Novy RE, Lin JL, Lin JJ (Oct 1991). "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem. 266 (25): 16917–24. doi:10.1016/S0021-9258(18)55390-4. PMID 1885618.

[entrez-4] "Entrez Gene: CALD1 caldesmon 1".

Caldesmon information

and 22 Related for: Caldesmon information

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