Solution structure of the CH domain of human Calponin 1. Rainbow colored cartoon (N-terminus = blue, C-terminus = red).[1]
Identifiers
Symbol
CNN1
NCBI gene
1264
HGNC
2155
OMIM
600806
PDB
1WYP
RefSeq
NM_001299
UniProt
P51911
Other data
Locus
Chr. 19 p13.2-13.1
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Structures
Swiss-model
Domains
InterPro
calponin 2
Identifiers
Symbol
CNN2
NCBI gene
1265
HGNC
2156
OMIM
602373
RefSeq
NM_004368
UniProt
Q99439
Other data
Locus
Chr. 19 p13.3
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Structures
Swiss-model
Domains
InterPro
calponin 3, acidic
Identifiers
Symbol
CNN3
NCBI gene
1266
HGNC
2157
OMIM
602374
RefSeq
NM_001839
UniProt
Q6FHA7
Other data
Locus
Chr. 1 p22-p21
Search for
Structures
Swiss-model
Domains
InterPro
Calponin is a calcium binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase, which is dependent upon calcium binding to calmodulin, releases the calponin's inhibition of the smooth muscle ATPase.
^PDB: 1WYP; Tomizawa T, Kigawa T, Koshiba S, Inoue M, Yokoyama S. "RCSB PDB - 1WYP Structure Summary". RCSB Protein Data Bank. doi:10.2210/pdb1wyp/pdb. {{cite journal}}: Cite journal requires |journal= (help)
Calponin is a calcium binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein...
encoding three isoforms of calponin: calponin 1, calponin 2, calponin 3, respectively. Protein sequence alignment shows that calponin 1 is highly conserved...
also known as neutral calponin. Calponin isoforms are conserved proteins whereas calponin 2 has diverged from calponin 1 and calponin 3 mainly in the C-terminal...
Calponin homology domain (or CH domain) is a family of actin binding domains found in both cytoskeletal proteins and signal transduction proteins. The...
In molecular biology, the calponin family repeat is a 26 amino acid protein domain. Calponin 1 (CNN1) contains three copies of this domain. This domain...
each of their polypeptide in which each ABD contains two of 125-residue calponin-homology (CH) components. This structure allows for plastins to cross-link...
iridophores have been found to contain the smooth muscle regulatory proteins [calponin] and caldesmon. Leaving the neural crest in waves, chromatophores take...
calmodulin (which takes on the regulatory role in smooth muscle), caldesmon and calponin are significant proteins expressed within smooth muscle. Tropomyosin is...
respectively, in lobular carcinoma in situ - Myoepithelial cell stain (calponin in this case) showing circumferential staining, rather than the absent...
encoded by the CALD1 gene. Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle...
LIM and calponin homology domains-containing protein 1 is a protein that in humans is encoded by the LIMCH1 gene. GRCh38: Ensembl release 89: ENSG00000064042...
protein important in the formation of filopodia. Fimbrin belongs to the calponin homology (CH) domain superfamily of actin cross-linking proteins. Like...
NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene. MICAL1 has been shown to interact...
myoepithelial marker proteins such as tumor protein 63, smooth muscle actin, calponin, or CD10. The diagnosis of ICCB tumors is based on the histopathology and...
filament protein tropomyosin and other notable proteins – caldesmon and calponin. Thus, smooth muscle contractions are initiated by the Ca2+ -activated...
also related to Calponin, a calcium binding protein. In the 324 to 403 base pair region, there is a Calponin homology domain. Calponin homology domains...
invasive cancer measuring up to 1.0 mm in size. Immunohistochemistry for calponin in ductal carcinoma in situ, highlighting myoepithelial cells around all...
factor (M-CSF). Certain markers, including CD140a+ , CD140b+ , α-SMA+ and Calponin+, indicate a perivascular origin of this cell line. OP9 cells have been...
vimentin protein, and collagen type IV protein, but not keratin, S100, calponin, or CD34 proteins. The finding that a tumor's cells have some of these...
about 50% of cases. Negative: Epithelial membrane antigen, desmin, p63 and calponin. Alcian blue will give a blue staining to the stromal matrix material....
Leucine-rich repeat and calponin homology domain-containing protein 4 is a protein that in humans is encoded by the LRCH4 gene. This gene encodes a protein...
Norwood FL, Moores CA, et al. (1999). "The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue...
PMID 9923700. Gusev NB (October 2001). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle...
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