Protein-coding gene in the species Homo sapiens
CX3CL1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B2T, 1F2L, 3ONA, 4XT1, 4XT3
Identifiers Aliases CX3CL1 , ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin, C-X3-C motif chemokine ligand 1External IDs OMIM: 601880 MGI: 1097153 HomoloGene: 2251 GeneCards: CX3CL1 Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 57,372,477 bp[1] End 57,385,044 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C5|8 46.79 cM Start 95,498,637 bp[2] End 95,509,055 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung right coronary artery prefrontal cortex frontal pole ascending aorta popliteal artery dorsolateral prefrontal cortex lactiferous duct upper lobe of left lung Brodmann area 10
Top expressed in entorhinal cortex visual cortex olfactory tubercle superior frontal gyrus primary motor cortex prefrontal cortex nucleus accumbens dentate gyrus subiculum medial dorsal nucleus
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
cytokine activity
chemokine activity
protein binding
CCR chemokine receptor binding
signaling receptor binding
integrin binding
CX3C chemokine receptor binding
Cellular component
integral component of membrane
membrane
plasma membrane
extracellular region
cell surface
extracellular space
Biological process
G protein-coupled receptor signaling pathway
defense response
positive regulation of inflammatory response
monocyte chemotaxis
cytokine-mediated signaling pathway
chemokine-mediated signaling pathway
angiogenesis involved in wound healing
cellular response to tumor necrosis factor
wound healing
leukocyte chemotaxis
neutrophil chemotaxis
positive regulation of angiogenesis
positive regulation of transforming growth factor beta1 production
positive regulation of GTPase activity
cell adhesion
immune response
cellular response to interleukin-1
leukocyte adhesive activation
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cell chemotaxis
lymphocyte chemotaxis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of calcium-independent cell-cell adhesion
chemotaxis
integrin activation
negative regulation of cell migration
leukocyte migration involved in inflammatory response
macrophage chemotaxis
regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 16: 57.37 – 57.39 Mb Chr 8: 95.5 – 95.51 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Fractalkine , also known as chemokine (C-X3-C motif) ligand 1 , is a protein that in humans is encoded by the CX3CL1 gene.
^ a b c GRCh38: Ensembl release 89: ENSG00000006210 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031778 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
Last Update: 2023-12-25T03:45:13Z
(C-X3-C motif) ligand 1, is a protein that in humans is encoded by the CX3CL1 gene. Fractalkine is a large cytokine protein of 373 amino acids, it contains...
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Last Update: 2023-12-11T02:47:05Z
CX3CR1 with CX3CL1 can mediate migration, adhesion and retention of leukocytes, because Fractalkine exists as membrane-anchored protein (mCX3CL1 ) as well...
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Last Update: 2023-12-03T11:52:39Z
d-chemokines). The only CX3C chemokine discovered to date is called fractalkine (or CX3CL1 ). It is both secreted and tethered to the surface of the cell that expresses...
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Last Update: 2024-04-20T20:11:20Z
Mahmoud; Heidary, Fatemeh (2019). "Tear and serum interleukin-8 and serum CX3CL1 , CCL2 and CCL5 in sulfur mustard eye-exposed patients". International Immunopharmacology...
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Last Update: 2023-10-30T10:06:21Z
Network Netrins or NTN1, class of proteins Neurotactin, protein now known as CX3CL1 Neurturin, glial protein This disambiguation page lists articles associated...
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Last Update: 2024-03-27T09:02:59Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
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Last Update: 2024-04-11T17:43:27Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
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Last Update: 2023-07-10T12:15:54Z
of SECRET protein from Ectromelia virus. The SECRET protein (left) and the SECRET protein bound to CX3CL1 (Right). The chemokine is shown in magenta....
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Last Update: 2024-03-25T12:28:05Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
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Last Update: 2024-05-08T15:44:25Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
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Last Update: 2024-04-17T16:37:13Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
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Last Update: 2024-02-20T02:47:19Z
CX3CR1 Agonists: Fractalkine (CX3CL1 )...
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Last Update: 2024-01-15T05:45:40Z
located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17. GRCh38: Ensembl release 89: ENSG00000102962 – Ensembl, May 2017...
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Last Update: 2023-06-11T00:48:30Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
Word Count : 184
Last Update: 2024-04-16T18:04:52Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
Word Count : 1706
Last Update: 2024-04-27T07:19:50Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
Word Count : 6302
Last Update: 2024-02-26T14:00:14Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
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Last Update: 2024-03-25T05:04:32Z
neurodevelopment may however be able to combat disease. The deletion of CX3CL1 , a highly expressed sensome gene, in rodent models of Rett syndrome resulted...
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Last Update: 2024-03-25T14:24:50Z
CX3CR1 Agonists: Fractalkine (CX3CL1 )...
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Last Update: 2024-04-25T22:44:33Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
Word Count : 316
Last Update: 2024-02-02T19:47:03Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
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Last Update: 2024-04-13T01:11:44Z
secreting chemokines such as CCL21 and surface immobilized chemokines such as CX3CL1 . Other glia such as astrocytes and oligodendrocytes may also release these...
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Last Update: 2024-04-29T05:37:30Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
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Last Update: 2024-05-06T05:32:07Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
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Last Update: 2024-03-24T06:27:38Z
CX3CR1 Agonists: Fractalkine (CX3CL1 )...
Word Count : 1671
Last Update: 2024-05-02T12:36:27Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
Word Count : 4194
Last Update: 2024-04-08T20:41:44Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
Word Count : 6477
Last Update: 2024-01-29T05:01:51Z
CCL28 CXCL CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2...
Word Count : 2645