Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Yverify (what is YN ?)
Infobox references
Chemical compound
CNQX or cyanquixaline (6-cyano-7-nitroquinoxaline-2,3-dione) is a competitive AMPA/kainate receptor antagonist. Its chemical formula is C9H4N4O4. CNQX is often used in the retina to block the responses of OFF-bipolar cells for electrophysiology recordings.[1]
CNQX is an antagonist of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs).[2] A study of the effects of CNQX on vestibuloocular reflex adaptation was done on goldfish by injecting CNQX into the vestibulo-cerebullum.[3] The injection before adaptation significantly decreased and at the highest doses, completely inhibited the acquisition of adaptive reflex gain increases and decreases during a three-hour training period. Baseline performance was not affected by the CNQX injections. Injections of CNQX at the end of the training period shows a rapid loss of gained vestibuloocular reflex adaptation when the goldfish remained stationary in the dark. Instead of injecting CNQX immediately after training, injection made one to two hours after the initiation of the training period showed no signs of altering performance. CNQX injections did not have long-term permanent effects on the goldfish's ability to be retrained 48-hours later and was comparable to a control group that was not subjected to CNQX injections. CNQX did not inhibit adaptive changes while the injection was administered.
^Sasaki T, Kaneko A (March 1996). "L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina". Vision Research. 36 (6): 787–95. doi:10.1016/0042-6989(95)00176-X. PMID 8736215. S2CID 17437312.
^Attwell PJ, Rahman S, Ivarsson M, Yeo CH (December 1999). "Cerebellar cortical AMPA-kainate receptor blockade prevents performance of classically conditioned nictitating membrane responses". The Journal of Neuroscience. 19 (24): RC45. doi:10.1523/JNEUROSCI.19-24-j0003.1999. PMC 6784969. PMID 10594089.
CNQX or cyanquixaline (6-cyano-7-nitroquinoxaline-2,3-dione) is a competitive AMPA/kainate receptor antagonist. Its chemical formula is C9H4N4O4. CNQX...
NBQX is soluble in water at high concentrations (at least up to 100 mM). CNQX DNQX Fanapanel (MPQX) Quinoxalinedione Pitt, D.; Werner, P.; Raine, C. S...
Global Information
verify (what is 
?)
